Probing the Cooperativity of Binding Networks with High-Throughput Thermophoresis.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.6b04861
Abstract: The formation of supramolecular complexes is found in many natural systems and is the basis for cooperative behavior. Here, we report on the development of a high-throughput platform to measure the complex binding behavior in… read more here.
Keywords: probing cooperativity; throughput; throughput thermophoresis; binding networks ... See more keywords
Programming Substrate-Independent Kinetic Barriers With Thermodynamic Binding Networks
Sign Up to like & getrecommendations! Published in 2021 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2019.2959310
Abstract: Engineering molecular systems that exhibit complex behavior requires the design of kinetic barriers. For example, an effective catalytic pathway must have a large barrier when the catalyst is absent. While programming such energy barriers seems… read more here.
Keywords: thermodynamic binding; binding networks; model; energy ... See more keywords