Beyond Competitive Binding: New Biochemical Insights Challenge Endocrine Disrupting Chemical Screening Paradigms.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental science & technology"
DOI: 10.1021/acs.est.5c07050
Abstract: Endocrine-disrupting chemicals (EDCs) pose significant health risks at environmentally relevant levels. Global screening efforts have predominantly relied on competitive binding assays. Here, using biochemical assays and computational simulations, we identified a crucial but largely overlooked… read more here.
Keywords: new biochemical; beyond competitive; biochemical insights; endocrine disrupting ... See more keywords
DFG-1 Binding: A New Residue for Developing Selective Kinase Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01501
Abstract: Only 15% of human kinases carry a bulky residue at the DFG-1 position, providing an opportunity for the design of selective ATP-site inhibitors without the typical hinge-binding interactions. The low sequence homology among unrelated kinases… read more here.
Keywords: dfg binding; kinase; binding new; new residue ... See more keywords
Ion-selective binding as a new trigger for micellization of block copolyelectrolytes with two anionic blocks.
Sign Up to like & getrecommendations! Published in 2019 at "Soft matter"
DOI: 10.1039/c9sm01138b
Abstract: This work presents well-defined and switchable micelles of block copolymers consisting of the two anionic polyelectrolytes sodium polyacrylate (NaPA) and sodium polystyrene sulfonate (NaPSS). Micellization occurs due to the specific binding of Ca2+ to acrylate… read more here.
Keywords: two anionic; block; binding new; micellization ... See more keywords