Harnessing the untapped potential of nucleotide‐binding oligomerization domain ligands for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21557
Abstract: In the last decade, cancer immunotherapy has emerged as an effective alternative to traditional therapies such as chemotherapy and radiation. In contrast to the latter, cancer immunotherapy has the potential to distinguish between cancer and… read more here.
Keywords: cancer; binding oligomerization; cancer immunotherapy; nucleotide binding ... See more keywords
Molecular cloning and functional characterization of duck nucleotide‐binding oligomerization domain 1 (NOD1)
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2017.04.012
Abstract: &NA; Nucleotide‐binding oligomerization domain 1 (NOD1) is an imperative cytoplasmic pattern recognition receptor (PRR) and considered as a key member of the NOD‐like receptor (NLR) family which plays a critical role in innate immunity through… read more here.
Keywords: nucleotide binding; binding oligomerization; duck; oligomerization domain ... See more keywords
Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.04.017
Abstract: Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory caspases triggers the oligomerization and lipid binding by its N-terminal domain, which assembles membrane… read more here.
Keywords: murine; lipid binding; binding oligomerization; crystal structures ... See more keywords
Activation of nucleotide-binding oligomerization domain-containing protein 1 by diaminopimelic acid contributes to cerebral ischemia-induced cognitive impairment
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135547
Abstract: Cerebral ischemia-reperfusion (I/R)-induced brain tissue injury is a major obstacle for acute stroke management. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is reported to play a critical role in the regulation of myocardial or hepatic I/R… read more here.
Keywords: nucleotide binding; cerebral ischemia; binding oligomerization; oligomerization domain ... See more keywords
Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44736-9
Abstract: Rif1 is a conserved protein regulating replication timing and binds preferentially to the vicinity of late-firing/dormant origins in fission yeast. The Rif1 binding sites on the fission yeast genome have an intrinsic potential to generate… read more here.
Keywords: rif1; promotes association; binding oligomerization; rif1 promotes ... See more keywords
Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac045
Abstract: Mutations in nucleotide-binding oligomerization domain 2 (NOD2) are associated with Crohn's disease (CD). Although NOD2 activation contributes to the maintenance of intestinal homeostasis through the negative regulation of pro-inflammatory cytokine responses mediated by Toll-like receptors… read more here.
Keywords: expression; nucleotide binding; oligomerization domain; binding oligomerization ... See more keywords
Mechanism of action of the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and its regulation in liver injury
Sign Up to like & getrecommendations! Published in 2024 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000003309
Abstract: Abstract Nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) is a cytosolic pattern recognition receptor that recognizes multiple pathogen-associated molecular patterns and damage-associated molecular patterns. It is a cytoplasmic immune factor that responds to cellular… read more here.
Keywords: receptor; nucleotide binding; oligomerization domain; injury ... See more keywords
Nucleotide-binding and oligomerization domain (NOD)-like receptors in teleost fish: Current knowledge and future perspectives.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of fish diseases"
DOI: 10.1111/jfd.12841
Abstract: Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are a group of intracellular pathogen recognition receptors (PRRs) that play key roles in pathogen recognition and subsequent activation of innate immune signalling pathways. Expressions of several NLR… read more here.
Keywords: nucleotide binding; binding oligomerization; nod like; oligomerization domain ... See more keywords
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-025-03399-2
Abstract: Histone lactylation, a newly glycosis-related histone modification, plays a crucial role in the regulation of gene expression in various immune cells. However, the role of histone lactylation in astrocytes remains unclear. Here, this study showed… read more here.
Keywords: h3k18 lactylation; domain nod2; nucleotide binding; lactylation ... See more keywords
Nucleotide‐Binding Oligomerization Domain (NOD)-Like Receptor Subfamily C (NLRC) as a Prognostic Biomarker for Glioblastoma Multiforme Linked to Tumor Microenvironment: A Bioinformatics, Immunohistochemistry, and Machine Learning-Based Study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s397305
Abstract: Purpose Glioblastoma multiforme (GBM) remains the deadliest primary brain tumor. We aimed to illuminate the role of nucleotide‐binding oligomerization domain (NOD)-like receptor subfamily C (NLRC) in GBM. Patients and Methods Based on public database data… read more here.
Keywords: nucleotide binding; analysis; oligomerization domain; binding oligomerization ... See more keywords
NOD2 (Nucleotide-Binding Oligomerization Domain-Containing Protein 2)-Mediated Modulation of the Immune Response Induced by BCG (Bacillus Calmette-Guérin) Bacilli
Sign Up to like & getrecommendations! Published in 2025 at "Pathogens"
DOI: 10.3390/pathogens14070683
Abstract: The Bacillus Calmette-Guérin (BCG) vaccine confers broad, non-specific immunity that may bolster defenses against respiratory viruses. While NOD2 (nucleotide-binding oligomerization domain-containing protein 2)-driven pathways are central to innate immune responses, the contribution of surface receptor… read more here.
Keywords: bcg; calmette rin; nucleotide binding; nod2 nucleotide ... See more keywords