Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions?
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1362-7
Abstract: Within the last years, for several ligands, binding to G protein-coupled receptors or other target proteins, a binding of the ligand in two different orientations is described. One appropriate experimental technique to detect two different… read more here.
Keywords: protein; detect two; binding orientations; distinct conditions ... See more keywords
The binding orientations of structurally-related ligands can differ; A cautionary note
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.01.023
Abstract: ABSTRACT Crystal structures can identify ligand‐receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both 5‐HT3 and &agr;7 nACh… read more here.
Keywords: binding orientations; nach receptors; agr nach; structurally related ... See more keywords