Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators
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DOI: 10.1371/journal.pone.0214255
Abstract: Allosteric ligands bind to receptors at sites that are distinct from those endogenous agonists and orthosteric pharmacological agents interact with. Both an allosteric and orthosteric ligand bind simultaneously to the receptor to form a ternary… read more here.
Keywords: two allosteric; allosteric modulators; orthosteric tracer; binding orthosteric ... See more keywords
Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites
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DOI: 10.3390/md16040109
Abstract: Diverse ligands of the muscle nicotinic acetylcholine receptor (nAChR) are used as muscle relaxants during surgery. Although a plethora of such molecules exists in the market, there is still a need for new drugs with… read more here.
Keywords: orthosteric allosteric; muscle nachr; allosteric sites; muscle ... See more keywords