Exploring Complexes of Rhodopsin and Binding Partners in Virtual Reality
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1936
Abstract: Protein structures are important for understanding biological processes on the most fundamental level. However, communicating 3D protein structures using 2D projections in publications or presentations does not deliver a complete representation of the important structural… read more here.
Keywords: binding partners; reality; virtual reality; rhodopsin binding ... See more keywords
Mapping Transmembrane Binding Partners for E-Cadherin Ectodomains
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DOI: 10.1016/j.bpj.2020.11.079
Abstract: We combine proximity labeling and single molecule binding assays to discover transmembrane protein interactions in cells. We first screen for candidate binding partners by tagging the extracellular and cytoplasmic regions of a "bait" protein with… read more here.
Keywords: binding partners; transmembrane binding; cadherin ectodomains; mapping transmembrane ... See more keywords
Activities and binding partners of E3 ubiquitin ligase DTX3L and its roles in cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20220501
Abstract: Ubiquitination is a protein post-translational modification that affects protein localisation, stability and interactions. E3 ubiquitin ligases regulate the final step of the ubiquitination reaction by recognising target proteins and mediating the ubiquitin transfer from an… read more here.
Keywords: dtx3l; ubiquitin ligase; activities binding; domain ... See more keywords
Abstract 2560: Identification and characterization of EWS-FLI1 binding partners in Ewing sarcoma cell lines
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2560
Abstract: Ewing sarcoma (ES) is characterized by a reciprocal translocation t(11;22) that results in a fusion of the EWSR1 and FLI1 genes (EWS-FLI). The objective of this study is to identify protein binding partners of the… read more here.
Keywords: ews fli1; cell lines; control; binding partners ... See more keywords
Novel binding partners for Prenylated Rab Acceptor 1 identified by a split-ubiquitin yeast two-hybrid screen
Sign Up to like & getrecommendations! Published in 2019 at "BMC Research Notes"
DOI: 10.1186/s13104-019-4219-y
Abstract: ObjectivePrenylated Rab Acceptor 1 (PRA1) is a transmembrane protein localized to the early secretory pathway. It has been found to interact with an array of Rab GTPases, leading to its hypothesized function in the recycling… read more here.
Keywords: split ubiquitin; binding partners; two hybrid; screen ... See more keywords
Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: theme and variations
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DOI: 10.1261/rna.079016.121
Abstract: Sensing of pathogen-associated molecular patterns including viral RNA by innate immunity represents the first line of defense against viral infection. In addition to RIG-I-like receptors and NOD-like receptors, several other RNA sensors are known to… read more here.
Keywords: rna binding; rna; rna sensors; innate antiviral ... See more keywords
Leveraging the Structure of DNAJA1 to Discover Novel Potential Pancreatic Cancer Therapies
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101391
Abstract: Pancreatic cancer remains one of the deadliest forms of cancer with a 5-year survival rate of only 11%. Difficult diagnosis and limited treatment options are the major causes of the poor outcome for pancreatic cancer.… read more here.
Keywords: pancreatic cancer; leveraging structure; dnaja1; cancer ... See more keywords
Affinity Purification of NF1 Protein–Protein Interactors Identifies Keratins and Neurofibromin Itself as Binding Partners
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10090650
Abstract: Neurofibromatosis Type 1 (NF1) is caused by pathogenic variants in the NF1 gene encoding neurofibromin. Definition of NF1 protein–protein interactions (PPIs) has been difficult and lacks replication, making it challenging to define binding partners that… read more here.
Keywords: protein; nf1 protein; binding partners; protein protein ... See more keywords
Novel Tsg101 Binding Partners Regulate Viral L Domain Trafficking
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DOI: 10.3390/v13061147
Abstract: Two decades ago, Tsg101, a component of the Endosomal Sorting Complexes Required for Transport (ESCRT) complex 1, was identified as a cellular factor recruited by the human immunodeficiency virus type 1 (HIV-1) to facilitate budding… read more here.
Keywords: binding partners; partners regulate; tsg101 binding; novel tsg101 ... See more keywords