Custom DNA microarrays reveal diverse binding preferences of proteins and small molecules to thousands of G-quadruplexes.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00934
Abstract: Single-stranded DNA (ssDNA) containing four guanine repeats can form G-quadruplex (G4) structures. While cellular proteins and small molecules can bind G4s, it has been difficult to broadly assess their DNA binding specificity. Here, we use… read more here.
Keywords: dna microarrays; custom dna; dna; small molecules ... See more keywords
ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24333-y
Abstract: Understanding blood group antigen binding preferences for C-type lectin receptors holds promise for modulating immune responses, since several Gram-negative bacteria express blood group antigens as molecular mimicry to evade immune responses. Herein, we report the… read more here.
Keywords: tri disaccharides; lectin receptor; type lectin; binding preferences ... See more keywords
Use of a fluorinated probe to quantitatively monitor amino acid binding preferences of ruthenium(ii) arene complexes.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c8dt05159c
Abstract: In order to address outstanding questions about ruthenium complexes in complex biological solutions, 19F NMR spectroscopy was used to follow the binding preferences between fluorinated RuII(η6-arene)(bipyridine) complexes and protected amino acids and glutathione. Reporting what… read more here.
Keywords: ruthenium; fluorinated probe; arene; solution phase ... See more keywords
RRMScorer: A web server for predicting RNA recognition motif binding preferences
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf367
Abstract: Abstract RRMScorer is a web server designed to predict RNA binding preferences for proteins containing RNA recognition motifs (RRMs), the most prevalent RNA binding domain in eukaryotes. By carefully analysing a dataset of 187 RRM–RNA… read more here.
Keywords: web server; rna recognition; binding preferences; rrmscorer web ... See more keywords
RAF Binding Preferences Dictate RAS-Mediated Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-158
Abstract: Distinct binding between RAS and RAF family members determines RAS signaling. read more here.
Keywords: mediated tumorigenesis; binding preferences; raf binding; preferences dictate ... See more keywords
Neural network modeling of differential binding between wild-type and mutant CTCF reveals putative binding preferences for zinc fingers 1–2
Sign Up to like & getrecommendations! Published in 2022 at "BMC Genomics"
DOI: 10.1186/s12864-022-08486-9
Abstract: Background Many transcription factors (TFs), such as multi zinc-finger (ZF) TFs, have multiple DNA binding domains (DBDs), and deciphering the DNA binding motifs of individual DBDs is a major challenge. One example of such a… read more here.
Keywords: ctcf; binding preferences; neural network; wild type ... See more keywords
Structures and nucleic acid-binding preferences of the eukaryotic ARID domain
Sign Up to like & getrecommendations! Published in 2022 at "Biological Chemistry"
DOI: 10.1515/hsz-2021-0404
Abstract: Abstract The DNA-binding AT-rich interactive domain (ARID) exists in a wide range of proteins throughout eukaryotic kingdoms. ARID domain-containing proteins are involved in manifold biological processes, such as transcriptional regulation, cell cycle control and chromatin… read more here.
Keywords: dna; binding preferences; domain; structures nucleic ... See more keywords