Novel auristatin E‐based albumin‐binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound
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DOI: 10.1016/j.jconrel.2019.01.010
Abstract: ABSTRACT Auristatins are a class of highly cytotoxic tubulin‐disrupting peptides, which have shown limited therapeutic effect as free agents in clinical trials. In our continuing effort to develop acid‐sensitive albumin‐binding anticancer drugs exploiting circulating serum… read more here.
Keywords: sulf07; binding prodrugs; albumin binding; auristatin ... See more keywords