DNA‐Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800273
Abstract: DNA minor groove binding polyamides have been extensively developed to control abnormal gene expression. The establishment of novel, inherently fluorescent 2‐(p‐anisyl)benzimidazole (Hx) amides has provided an alternative path for studying DNA binding in cells by… read more here.
Keywords: azahx; pyr azahx; dna; azahx amides ... See more keywords
Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4396
Abstract: PDZ domains are the most diffused protein–protein interaction modules of the human proteome and are often present in tandem repeats. An example is PDZD2, a protein characterized by the presence of six PDZ domains that… read more here.
Keywords: folding intermediate; pdz; pdz domains; binding properties ... See more keywords
Amine-binding properties of salivary yellow-related proteins in phlebotomine sand flies.
Sign Up to like & getrecommendations! Published in 2019 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2019.103245
Abstract: The amine-binding properties of sand fly salivary yellow-related proteins (YRPs) were described only in Lutzomyia longipalpis sand flies. Here, we experimentally confirmed the kratagonist function of YRPs in the genus Phlebotomus. We utilized microscale thermophoresis… read more here.
Keywords: sand; amine binding; related proteins; salivary yellow ... See more keywords
Exploring high-affinity binding properties of octamer peptides by principal component analysis of tetramer peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2016.08.005
Abstract: To investigate the binding properties of a peptide sequence, we conducted principal component analysis (PCA) of the physicochemical features of a tetramer peptide library comprised of 512 peptides, and the variables were reduced to two… read more here.
Keywords: high affinity; affinity; principal component; tetramer ... See more keywords
Binding properties of pyrene-porphyrin dyad to G-quadruplexes in the presence of K+ and Na+ ion and their effect on stability
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128264
Abstract: Abstract The binding property of 1-pyrenyl-tris(N-methyl-p-pyridino)porphyrin (a pyrene-porphyrin dyad; Py-TMPyP) to various G-quadruplexes formed from 5′-G3TnG3TGTG3TnG3 (n = 2 and 3, designated as S1 and S2, respectively) and conformation-dependent stability of the Py-TMPyP–quadruplex complexes were investigated via… read more here.
Keywords: presence; porphyrin dyad; stability; binding properties ... See more keywords
Exploratory spectroscopic and computational studies of the anion binding properties of methyl hyocholate in organic solvent
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.02.015
Abstract: The binding properties of methyl hyocholate 1a toward F−, Cl−, Br− and CH3CO2− anions were explored by 1H and 13C NMR, ESI-MS measurements and computational calculations. The 1H NMR titration suggested that 1a forms a… read more here.
Keywords: properties methyl; spectroscopic computational; methyl hyocholate; exploratory spectroscopic ... See more keywords
Protein adduct binding properties of tabun-subtype nerve agents after exposure in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.12.014
Abstract: Upon entering the body, nerve agents can bind active amino acid residues to form phosphonylated adducts. Tabun derivatives (O-alkyl-N,N-dialkyl phosphoroamidocyanidates) have strikingly different structural features from other G-series nerve agents, such as sarin and soman.… read more here.
Keywords: properties tabun; tabun derivatives; binding properties; nerve agents ... See more keywords
T160A mutation-induced deglycosylation at site 158 in hemagglutinin is a critical determinant of the dual receptor binding properties of clade 2.3.4.4 H5NX subtype avian influenza viruses.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2018.03.018
Abstract: Most clade 2.3.4.4 H5NX subtype avian influenza viruses possess a T160A amino acid substitution in the hemagglutinin (HA) protein that has been shown to affect the receptor binding properties of a clade 2.3.4 H5N1 virus.… read more here.
Keywords: clade h5nx; site 158; receptor; binding properties ... See more keywords
Identification of Kazal Inhibitor Scaffolds with Identical Canonical Binding Loops and Their Effects on Binding Properties
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00573
Abstract: Kazal inhibitors hold high potential as scaffolds for therapeutic molecules, taking advantage of the easily exchangeable canonical binding loop. Different Kazal inhibitor backbones have been suggested to be therapeutically useful, but the impact of different… read more here.
Keywords: kazal inhibitor; canonical binding; binding properties; inhibitor ... See more keywords
Insight into the Soil Dissolved Organic Matter Ligand-Phenanthrene-Binding Properties Based on Parallel Faction Analysis Combined with Two-Dimensional Correlation Spectroscopy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06013
Abstract: Dissolved organic matter (DOM) can strongly bind to organic contaminants and control phenanthrene in soil. Herein, four individual parallel factor analysis (PARAFAC) components were found in soil DOM. Component C1 was the humic-like component ligand… read more here.
Keywords: dom; phenanthrene binding; spectroscopy; binding properties ... See more keywords
Influence of Melanin Characteristics on Drug Binding Properties.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00157
Abstract: Melanins are biopolymers encompassing a high degree of chemical heterogeneity. Binding of small-molecule drugs to ocular melanin significantly affects the ocular pharmacokinetics, and could serve as a strategy for prolonged drug retention in the eye.… read more here.
Keywords: drug binding; melanin; small molecule; drug ... See more keywords