The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14415
Abstract: Mitochondria are involved in many cellular activities, including energy metabolism and biosynthesis of nucleotides, fatty acids and amino acids. Mitochondrial morphology is a key factor in dictating mitochondrial functions. Here, we report that the acyl‐CoA‐binding… read more here.
Keywords: binding protein; coa binding; lipid droplets; acb1 regulates ... See more keywords
The autophagy initiation factor ATG13 mRNA is stabilized by the RNA‐binding protein YBX3
Sign Up to like & getrecommendations! Published in 2024 at "Febs Letters"
DOI: 10.1002/1873-3468.15035
Abstract: Autophagy, a highly conserved form of cellular recycling, is essential for cellular homeostasis. Its dysregulation has been linked to neurodegenerative diseases and various cancers, including breast cancer. We set out to determine if the RNA‐binding… read more here.
Keywords: ybx3; binding protein; initiation factor; autophagy initiation ... See more keywords
The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Oncology"
DOI: 10.1002/1878-0261.70060
Abstract: Oncoprotein Y‐box‐binding protein‐1 (YB‐1) is involved in all cancer hallmarks. One of the most studied post‐translational modifications of YB‐1 is phosphorylation on Serine 102 (S102), which is involved in cancer progression. KRAS mutations are frequent,… read more here.
Keywords: cancer; kras mutation; box binding; binding protein ... See more keywords
Selection of an artificial paraquat-specific binding protein from a ribosome display library based on a lipocalin scaffold.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2059
Abstract: In this study, an anticalin that could specifically bind paraquat (PQ), a quaternary nitrogen herbicide, as a new set of engineered receptor protein with antibody-like properties was generated to detect PQ concentration. To this end,… read more here.
Keywords: library; selection artificial; ribosome display; binding protein ... See more keywords
Characterization of maltose‐binding protein–fused heparinases with enhanced thermostability by application of rigid and flexible linkers
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2642
Abstract: Heparinases, including heparinases I–III (HepI, HepII, and HepIII, respectively), are important tools for producing low‐molecular‐weight heparin, an improved anticoagulant. The poor thermostability of heparinases significantly hinders their industrial and laboratory applications. To improve the thermostability… read more here.
Keywords: thermostability; linker; binding protein; mbp fused ... See more keywords
Final analysis of a phase I/IIa trial of the folate‐binding protein‐derived E39 peptide vaccine to prevent recurrence in ovarian and endometrial cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2378
Abstract: E39, an HLA‐A2‐restricted, immunogenic peptide derived from the folate‐binding protein (FBP), is overexpressed in multiple malignancies. We conducted a phase I/IIa trial of the E39 + GM‐CSF vaccine with booster inoculations of either E39 or… read more here.
Keywords: iia trial; phase iia; binding protein; cancer ... See more keywords
MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2919
Abstract: Osteosarcoma is a primary malignant bone tumor, which affects children, adolescents, and young adults commonly. MicroRNAs (miRNAs) have been proved to be dysregulated in different cancers, including osteosarcoma. Although miR‐320a has been implicated in many… read more here.
Keywords: cytoplasmic polyadenylation; polyadenylation element; osteosarcoma; binding protein ... See more keywords
Hyaluronan‐binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11326
Abstract: Hyaluronan‐binding protein 1 (HABP1), a multi‐compartmental, multi‐functional protein has a wide range of functions, which can be attributed to its ability to associate with a variety of cellular ligands. Earlier we have reported that HABP1… read more here.
Keywords: protein; senescence; hyaluronan binding; habp1 overexpression ... See more keywords
Y‐box binding protein 1 stabilizes EP300 mRNA and promotes forkhead box C1 H3K27Ac to aggravate chondrocyte injury in osteoarthritis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cell Communication and Signaling"
DOI: 10.1002/ccs3.70028
Abstract: Chondrocyte abnormalities play an important role in osteoarthritis (OA), and forkhead box C1 (FOXC1) expression is related to OA progression. Nonetheless, the molecular mechanisms underlying the action of FOXC1 in chondrocytes remain unclear. Rats were… read more here.
Keywords: ep300 mrna; box binding; forkhead box; binding protein ... See more keywords
Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid‐binding protein 5
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14318
Abstract: The activation of cardiac fibroblasts (CFs) leads to overproduction of collagens and subsequently cardiac fibrosis. However, the regulatory mechanism of CF function in the process of cardiac fibrosis remains unclear. This work investigated the function… read more here.
Keywords: binding protein; cardiac fibrosis; polypyrimidine tract; fibrosis ... See more keywords
Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202149781
Abstract: The RNA-binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1) has been found to have roles in CD4 T cell activation, but its function in CD8 T cells remains untested. We show it is dispensable for… read more here.
Keywords: activation; cd8 cells; polypyrimidine tract; cd8 ... See more keywords