The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14415
Abstract: Mitochondria are involved in many cellular activities, including energy metabolism and biosynthesis of nucleotides, fatty acids and amino acids. Mitochondrial morphology is a key factor in dictating mitochondrial functions. Here, we report that the acyl‐CoA‐binding… read more here.
Keywords: binding protein; coa binding; lipid droplets; acb1 regulates ... See more keywords
Selection of an artificial paraquat-specific binding protein from a ribosome display library based on a lipocalin scaffold.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2059
Abstract: In this study, an anticalin that could specifically bind paraquat (PQ), a quaternary nitrogen herbicide, as a new set of engineered receptor protein with antibody-like properties was generated to detect PQ concentration. To this end,… read more here.
Keywords: library; selection artificial; ribosome display; binding protein ... See more keywords
Final analysis of a phase I/IIa trial of the folate‐binding protein‐derived E39 peptide vaccine to prevent recurrence in ovarian and endometrial cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2378
Abstract: E39, an HLA‐A2‐restricted, immunogenic peptide derived from the folate‐binding protein (FBP), is overexpressed in multiple malignancies. We conducted a phase I/IIa trial of the E39 + GM‐CSF vaccine with booster inoculations of either E39 or… read more here.
Keywords: iia trial; phase iia; binding protein; cancer ... See more keywords
MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2919
Abstract: Osteosarcoma is a primary malignant bone tumor, which affects children, adolescents, and young adults commonly. MicroRNAs (miRNAs) have been proved to be dysregulated in different cancers, including osteosarcoma. Although miR‐320a has been implicated in many… read more here.
Keywords: cytoplasmic polyadenylation; polyadenylation element; osteosarcoma; binding protein ... See more keywords
Hyaluronan‐binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11326
Abstract: Hyaluronan‐binding protein 1 (HABP1), a multi‐compartmental, multi‐functional protein has a wide range of functions, which can be attributed to its ability to associate with a variety of cellular ligands. Earlier we have reported that HABP1… read more here.
Keywords: protein; senescence; hyaluronan binding; habp1 overexpression ... See more keywords
Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid‐binding protein 5
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14318
Abstract: The activation of cardiac fibroblasts (CFs) leads to overproduction of collagens and subsequently cardiac fibrosis. However, the regulatory mechanism of CF function in the process of cardiac fibrosis remains unclear. This work investigated the function… read more here.
Keywords: binding protein; cardiac fibrosis; polypyrimidine tract; fibrosis ... See more keywords
Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202149781
Abstract: The RNA-binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1) has been found to have roles in CD4 T cell activation, but its function in CD8 T cells remains untested. We show it is dispensable for… read more here.
Keywords: activation; cd8 cells; polypyrimidine tract; cd8 ... See more keywords
Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28941
Abstract: Blocking hepatic very low‐density lipoprotein secretion through genetic or pharmacologic inhibition of microsomal triglyceride transfer protein (Mttp) causes hepatic steatosis, yet the risks for developing hepatic fibrosis are poorly understood. We report that liver‐specific Mttp… read more here.
Keywords: fibrosis; mttp; binding protein; mice ... See more keywords
Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31328
Abstract: Iron is essential yet also highly chemically reactive and potentially toxic. The mechanisms that allow cells to use iron safely are not clear; defects in iron management are a causative factor in the cell‐death pathway… read more here.
Keywords: iron; poly binding; iron chaperone; binding protein ... See more keywords
The role of cold‐inducible RNA binding protein in cell stress response
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30833
Abstract: Cold‐inducible RNA binding protein (CIRP) was discovered after the cells were exposed to a moderate cold shock because its production was induced. Other cellular stresses such as ultraviolet light radiation and hypoxia also could increase… read more here.
Keywords: inducible rna; rna binding; binding protein; cold inducible ... See more keywords
TAR DNA‐binding protein 43 oligomers in physiology and pathology
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2603
Abstract: TAR DNA‐binding protein 43 (TDP‐43) is an RNA/DNA‐binding protein involved in RNA regulation and diseases. In 2006, TDP‐43 inclusions were found in the disease lesions of several neurodegenerative diseases. It is the pathological hallmark in… read more here.
Keywords: binding protein; dna binding; pathology; physiology ... See more keywords