Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing.
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral research"
DOI: 10.1016/j.antiviral.2021.105139
Abstract: Because ganciclovir resistance mutations in the cytomegalovirus UL97 gene most commonly occur at codons 460, 520 and 590-607, diagnostic genotyping for drug resistance has often omitted the analysis of codons below 440. However, the UL97… read more here.
Keywords: binding region; maribavir; ganciclovir maribavir; atp binding ... See more keywords
A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemistry"
DOI: 10.1038/nchem.2754
Abstract: The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer's. There is considerable interest in discovering the minimal sequence and active conformational nucleus that defines this self-propagating event. The microtubule-binding region, spanning residues… read more here.
Keywords: binding region; aggregation; microtubule binding; aggregation tau244 ... See more keywords