Ligand specificity and affinity in the sulforhodamine B binding RNA aptamer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.056
Abstract: Binding affinity and selectivity are critical properties of aptamers that must be optimized for any application. The sulforhodamine B binding RNA aptamer (SRB-2) is a somewhat promiscuous aptamer that can bind ligands that vary markedly… read more here.
Keywords: binding rna; affinity; sulforhodamine binding; rna aptamer ... See more keywords
Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1054
Abstract: The enteroviral 2C protein is a therapeutic target, but the absence of a mechanistic framework for this enzyme limits our understanding of inhibitor mechanisms. Here we use poliovirus 2C and a derivative thereof to elucidate… read more here.
Keywords: step; uses two; enteroviral protein; rna ... See more keywords
The RNA-Binding and RNA-Melting Activities of the Multifunctional Protein Nucleobindin 1
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076193
Abstract: Nucleobindin 1 (NUCB1) is a ubiquitous multidomain protein that belongs to the EF-hand Ca2+-binding superfamily. NUCB1 interacts with Galphai3 protein, cyclooxygenase, amyloid precursor protein, and lipids. It is involved in stress response and human diseases.… read more here.
Keywords: rna melting; rna binding; activities multifunctional; binding rna ... See more keywords