Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain
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DOI: 10.1111/cas.14279
Abstract: The tumor suppressor gene p53 encodes a transcriptional activator that has two transactivation domains (TAD) located in its amino terminus. These two TAD can transactivate genes independently, and at least one TAD is required for… read more here.
Keywords: transactivation; target genes; binding sequences; p53 ... See more keywords
Inferred regulons are consistent with regulator binding sequences in E. coli
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DOI: 10.1371/journal.pcbi.1011824
Abstract: The transcriptional regulatory network (TRN) of E. coli consists of thousands of interactions between regulators and DNA sequences. Regulons are typically determined either from resource-intensive experimental measurement of functional binding sites, or inferred from analysis… read more here.
Keywords: binding sequences; inferred regulons; ica inferred; regulator ... See more keywords