Docking and molecular simulations reveal a quinone binding site on the surface of respiratory complex I.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14346
Abstract: The first component of the mitochondrial electron transport chain is respiratory complex I. Several high-resolution structures of complex I from different species have been resolved. However, despite these significant achievements, the mechanism of redox-coupled proton… read more here.
Keywords: surface; docking molecular; binding site; site ... See more keywords
Is a microRNA‐328 binding site in PAX6 associated with Rolandic epilepsy?
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.401
Abstract: Is a microRNA-328 binding site in PAX6 associated with Rolandic epilepsy? Amelia McGlade, Kenneth A. Myers, Samuel F. Berkovic, Ingrid E. Scheffer, Slav e Petrovski & Michael S. Hildebrand* Epilepsy Research Centre, Department of Medicine,… read more here.
Keywords: epilepsy; medicine; microrna 328; site pax6 ... See more keywords
Development of heterodimeric estrogen receptor alpha antagonists to target simultaneously the ligand and coactivator binding site.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200638
Abstract: One-third of breast cancer patients will develop recurrent cancer within 15 years of endocrine treatment. Notably, tumor growth in a hormone-refractory state still relies on the interaction between estrogen receptor alpha (ERα) and upregulated coactivators.… read more here.
Keywords: binding site; site; estrogen receptor; coactivator binding ... See more keywords
Second Coordination Sphere Effects on the Mechanistic Pathways for Dioxygen Activation by a Ferritin: Involvement of a Tyr Radical and the Identification of a Cation Binding Site
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200257
Abstract: Ferritins are ubiquitous diiron enzymes involved in iron(II) detoxification and oxidative stress responses and can act as metabolic iron stores. The overall reaction mechanisms of ferritin enzymes are still unclear, particularly concerning the role of… read more here.
Keywords: ferritin; cation binding; coordination sphere; binding site ... See more keywords
The noncanonical nucleotide binding site 1 of the bile salt export pump is optimized for proper function of the transporter
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12136
Abstract: The bile salt export pump (ABCB11/BSEP) is a hepatocyte plasma membrane‐resident protein translocating bile salts into bile canaliculi. The sequence alignment of the four full‐length transporters of the ABCB subfamily (ABCB1, ABCB4, ABCB5 and ABCB11)… read more here.
Keywords: binding site; bile salt; nucleotide binding; salt export ... See more keywords
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR)
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300048
Abstract: In this study we present MS Binding Assays for the PCP ion channel binding site of Torpedo californica nicotinic acetylcholine receptor (nAChR) as an alternative to radioligand binding assays. As MS Marker Benocyclidine (BTCP) was… read more here.
Keywords: pcp ion; ion channel; channel binding; binding site ... See more keywords
The Usage of ACCLUSTER for Peptide Binding Site Prediction.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6798-8_1
Abstract: Peptides mediate up to 40 % of protein-protein interactions in a variety of cellular processes and are also attractive drug candidates. Thus, predicting peptide binding sites on the given protein structure is of great importance… read more here.
Keywords: peptide binding; accluster; accluster peptide; binding site ... See more keywords
Refining the Quality of Monoclonal Antibodies: Grafting Unique Peptide-Binding Site in the Fab Framework.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8958-4_12
Abstract: Monoclonal antibodies (mAbs) are a major therapeutic modality. Grafting the meditope binding site onto mAbs, also known as meditope-enabling, can extend the usefulness of mAbs by providing an additional protein-protein interaction surface without altering the… read more here.
Keywords: refining quality; monoclonal antibodies; binding site; quality monoclonal ... See more keywords
Identification of potential human targets for epigallocatechin gallate through a novel protein binding site screening approach
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-025-06410-y
Abstract: Epigallocatechin-3-gallate (EGCG), a compound found in green tea, is known for its anticancer properties, although its specific protein targets remain largely undefined. In this study, we identified EGCG targets across the human proteome using a… read more here.
Keywords: binding site; site screening; novel protein; protein ... See more keywords
Estimating genetic diversity among selected wild grapevine genotypes from Southern Turkey by simple sequence repeat (SSR) and inter-Primer Binding Site(iPBS) markers
Sign Up to like & getrecommendations! Published in 2024 at "Genetic Resources and Crop Evolution"
DOI: 10.1007/s10722-024-02102-3
Abstract: The examination of germplasm within grapevine accessions derived from wild genotypes holds significant importance within the grapevine breeding program, particularly in the improving of cultivars and rootstocks. Due to the greater genetic variation present in… read more here.
Keywords: binding site; grapevine genotypes; ipbs markers; primer binding ... See more keywords
Dynamics and binding interactions of peptide inhibitors of dengue virus entry
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biological Physics"
DOI: 10.1007/s10867-018-9515-6
Abstract: In this study, we investigate the binding interactions of two synthetic antiviral peptides (DET2 and DET4) on type II dengue virus (DENV2) envelope protein domain III. These two antiviral peptides are designed based on the… read more here.
Keywords: dengue virus; dynamics binding; binding site; binding interactions ... See more keywords