Docking and molecular simulations reveal a quinone binding site on the surface of respiratory complex I.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14346
Abstract: The first component of the mitochondrial electron transport chain is respiratory complex I. Several high-resolution structures of complex I from different species have been resolved. However, despite these significant achievements, the mechanism of redox-coupled proton… read more here.
Keywords: surface; docking molecular; binding site; site ... See more keywords
Is a microRNA‐328 binding site in PAX6 associated with Rolandic epilepsy?
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.401
Abstract: Is a microRNA-328 binding site in PAX6 associated with Rolandic epilepsy? Amelia McGlade, Kenneth A. Myers, Samuel F. Berkovic, Ingrid E. Scheffer, Slav e Petrovski & Michael S. Hildebrand* Epilepsy Research Centre, Department of Medicine,… read more here.
Keywords: epilepsy; medicine; microrna 328; site pax6 ... See more keywords
Development of heterodimeric estrogen receptor alpha antagonists to target simultaneously the ligand and coactivator binding site.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200638
Abstract: One-third of breast cancer patients will develop recurrent cancer within 15 years of endocrine treatment. Notably, tumor growth in a hormone-refractory state still relies on the interaction between estrogen receptor alpha (ERα) and upregulated coactivators.… read more here.
Keywords: binding site; site; estrogen receptor; coactivator binding ... See more keywords
Second Coordination Sphere Effects on the Mechanistic Pathways for Dioxygen Activation by a Ferritin: Involvement of a Tyr Radical and the Identification of a Cation Binding Site
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200257
Abstract: Ferritins are ubiquitous diiron enzymes involved in iron(II) detoxification and oxidative stress responses and can act as metabolic iron stores. The overall reaction mechanisms of ferritin enzymes are still unclear, particularly concerning the role of… read more here.
Keywords: ferritin; cation binding; coordination sphere; binding site ... See more keywords
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR)
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300048
Abstract: In this study we present MS Binding Assays for the PCP ion channel binding site of Torpedo californica nicotinic acetylcholine receptor (nAChR) as an alternative to radioligand binding assays. As MS Marker Benocyclidine (BTCP) was… read more here.
Keywords: pcp ion; ion channel; channel binding; binding site ... See more keywords
The Usage of ACCLUSTER for Peptide Binding Site Prediction.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6798-8_1
Abstract: Peptides mediate up to 40 % of protein-protein interactions in a variety of cellular processes and are also attractive drug candidates. Thus, predicting peptide binding sites on the given protein structure is of great importance… read more here.
Keywords: peptide binding; accluster; accluster peptide; binding site ... See more keywords
Refining the Quality of Monoclonal Antibodies: Grafting Unique Peptide-Binding Site in the Fab Framework.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8958-4_12
Abstract: Monoclonal antibodies (mAbs) are a major therapeutic modality. Grafting the meditope binding site onto mAbs, also known as meditope-enabling, can extend the usefulness of mAbs by providing an additional protein-protein interaction surface without altering the… read more here.
Keywords: refining quality; monoclonal antibodies; binding site; quality monoclonal ... See more keywords
Dynamics and binding interactions of peptide inhibitors of dengue virus entry
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biological Physics"
DOI: 10.1007/s10867-018-9515-6
Abstract: In this study, we investigate the binding interactions of two synthetic antiviral peptides (DET2 and DET4) on type II dengue virus (DENV2) envelope protein domain III. These two antiviral peptides are designed based on the… read more here.
Keywords: dengue virus; dynamics binding; binding site; binding interactions ... See more keywords
COLIA1 + 1245 G > T Sp1 Binding Site Polymorphism is Not Associated with ACL Injury Risks Among Indian Athletes.
Sign Up to like & getrecommendations! Published in 2020 at "Indian journal of orthopaedics"
DOI: 10.1007/s43465-020-00119-1
Abstract: Objective Type I collagen polypeptides contribute significantly to the structural composition of ligament tissue matrix. Since anterior cruciate ligament (ACL) tears account for roughly 50% of all knee injuries in sports, the objective of the… read more here.
Keywords: binding site; indian athletes; acl injury; sp1 ... See more keywords
The AMPA receptor biophysical gating properties and binding site: Focus on novel curcumin-based diazepines as non-competitive antagonists.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105406
Abstract: INTRODUCTION Investigating the binding site of six novel curcumin-based diazepine compounds as a non-competitive antagonist on ionotropic, AMPA-type glutamate receptors, including homomeric and heteromeric subunits. These receptors play a pivotal role in neurodegenerative diseases such… read more here.
Keywords: binding site; non competitive; biophysical gating; curcumin based ... See more keywords
Structure-Based Discovery of Novel Glycinergic Modulators
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2998
Abstract: Marijuana's analgesic effects can be attributed to the allosteric modulation of glycine receptors (GlyRs) by Δ9-tetrahydrocannabinol (THC). GlyRs are pentameric ligand-gated chloride channels that control inhibitory neurotransmission in the brainstem and spinal cord. The glycinergic… read more here.
Keywords: based discovery; binding site; structure based; thc binding ... See more keywords