Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y6
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202100683
Abstract: Cyclooxygenase‐2 catalyzes the biosynthesis of prostaglandins from arachidonic acid and the biosynthesis of prostaglandin glycerol esters (PG‐Gs) from 2‐arachidonoylglycerol. PG‐Gs are mediators of several biological actions such as macrophage activation, hyperalgesia, synaptic plasticity, and intraocular… read more here.
Keywords: ester; receptor p2y6; mapping binding; p2y6 ... See more keywords
Localizing Binding Sites on Bioconjugated Hydrogen‐Bonded Organic Semiconductors at the Nanoscale
Sign Up to like & getrecommendations! Published in 2019 at "Chemphyschem"
DOI: 10.1002/cphc.201901064
Abstract: Abstract Hydrogen‐bonded organic semiconductors are extraordinarily stable organic solids forming stable, large crystallites with the ability to preserve favorable electrical properties upon bioconjugation. Lately, tremendous efforts have been made to use these bioconjugated semiconductors as… read more here.
Keywords: hydrogen bonded; hydrogen; organic semiconductors; binding sites ... See more keywords
Functional defect of variants in the adenosine triphosphate–binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX‐770)
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28929
Abstract: ABCB4 (MDR3) is an adenosine triphosphate (ATP)‐binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Variations in the ABCB4 gene are responsible for several biliary diseases, including… read more here.
Keywords: ivacaftor; ivacaftor 770; sites abcb4; potentiator ... See more keywords
GCNF regulates OCT4 expression through its interactions with nuclear receptor binding elements in NCCIT cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26438
Abstract: We demonstrate that OCT4 expression is regulated by germ cell nuclear factor (GCNF) via its interactions with three nuclear receptor (NR) binding sites within OCT4 promoter conserved regions (CRs) in human embryonic carcinoma (EC) NCCIT… read more here.
Keywords: nccit cells; oct4 expression; binding sites; expression ... See more keywords
Targeting BAX ubiquitin‐binding sites reveals that BAX activation is essential for its ubiquitin‐dependent degradation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29505
Abstract: BAX is an important proapoptotic protein of the BCL‐2 family, and its stability is essential for the regulation of the mitochondrial apoptotic pathway. A previous study revealed that BAX could undergo degradation through the ubiquitin‐proteasome… read more here.
Keywords: bax; degradation; ubiquitin binding; binding sites ... See more keywords
Structural analysis of human G‐protein‐coupled receptor 17 ligand binding sites
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30388
Abstract: The human G protein coupled membrane receptor (GPR17), the sensor of brain damage, is identified as a biomarker for many neurological diseases. In human brain tissue, GPR17 exist in two isoforms, long and short. While… read more here.
Keywords: ligand binding; gpr17; receptor; binding sites ... See more keywords
Extension and refinement of the recognition motif for Toll‐like receptor 5 activation by flagellin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3vma0118-035r
Abstract: TLRs sense conserved and essential molecular components of microbes that invade multicellular organisms. The wide range of TLR agonists, differing in size and shape, is recognized either through a single or a pair of binding… read more here.
Keywords: recognition; binding sites; receptor; flagellin ... See more keywords
Prediction of Protein Metal Binding Sites Using Deep Neural Networks
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Informatics"
DOI: 10.1002/minf.201800169
Abstract: Metals have crucial roles for many physiological, pathological and diagnostic processes. Metal binding proteins or metalloproteins are important for metabolism functions. The proteins that reach the three‐dimensional structure by folding show which vital function is… read more here.
Keywords: metal binding; prediction protein; metal; binding sites ... See more keywords
Translating from Proteins to Ribonucleic Acids for Ligand‐binding Site Detection
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Informatics"
DOI: 10.1002/minf.202200059
Abstract: Identifying druggable ligand‐binding sites on the surface of the macromolecular targets is an important process in structure‐based drug discovery. Deep‐learning models have been shown to successfully predict ligand‐binding sites of proteins. As a step toward… read more here.
Keywords: acids ligand; ligand binding; translating proteins; ribonucleic acids ... See more keywords
In Silico Analysis of Class III Peroxidases: Hypothetical Structure, Ligand Binding Sites, Posttranslational Modifications, and Interaction with Substrates.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0528-8_24
Abstract: Functional analyses of peroxidases are a major challenge. In silico analysis appears to be a powerful tool to overcome at least some of the problems that arose from (1) the numerous possible functions of peroxidases,… read more here.
Keywords: analysis; class iii; silico analysis; binding sites ... See more keywords
RBPmap: A Tool for Mapping and Predicting the Binding Sites of RNA-Binding Proteins Considering the Motif Environment.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1851-6_3
Abstract: RNA-binding proteins (RBPs) play a key role in post-transcriptional regulation via binding to coding and non-coding RNAs. Recent development in experimental technologies, aimed to identify the targets of RBPs, has significantly broadened our knowledge on… read more here.
Keywords: rbpmap; binding proteins; mapping predicting; rna binding ... See more keywords