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   Articles with "binding sites" as a keyword



Mapping secondary substrate‐binding sites on the GH11 xylanase from Bacillus subtilis

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recommendations! Published in 2024 at "FEBS Letters"

DOI: 10.1002/1873-3468.14799

Abstract: Xylanases are of significant interest for biomass conversion technologies. Here, we investigated the allosteric regulation of xylan hydrolysis by the Bacillus subtilis GH11 endoxylanase. Molecular dynamics simulations (MDS) in the presence of xylobiose identified binding… read more here.

Keywords: bacillus subtilis; mapping secondary; sbs around; binding sites ... See more keywords

Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y6

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recommendations! Published in 2022 at "Chemmedchem"

DOI: 10.1002/cmdc.202100683

Abstract: Cyclooxygenase‐2 catalyzes the biosynthesis of prostaglandins from arachidonic acid and the biosynthesis of prostaglandin glycerol esters (PG‐Gs) from 2‐arachidonoylglycerol. PG‐Gs are mediators of several biological actions such as macrophage activation, hyperalgesia, synaptic plasticity, and intraocular… read more here.

Keywords: ester; receptor p2y6; mapping binding; p2y6 ... See more keywords

Insights into Molecular Interactions and Biological Effect of Natural Stilbenoids at the TRPA1 Ion Channel

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recommendations! Published in 2024 at "Chemmedchem"

DOI: 10.1002/cmdc.202400501

Abstract: Natural stilbenoids, polyphenolic compounds notably found in Scots pine and Norway spruce, have been shown to exhibit analgesic and anti‐inflammatory effects through the TRPA1 channel, making them promising hits for the development of novel agents… read more here.

Keywords: stilbenoids trpa1; natural stilbenoids; biological effect; binding sites ... See more keywords
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Localizing Binding Sites on Bioconjugated Hydrogen‐Bonded Organic Semiconductors at the Nanoscale

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recommendations! Published in 2019 at "Chemphyschem"

DOI: 10.1002/cphc.201901064

Abstract: Abstract Hydrogen‐bonded organic semiconductors are extraordinarily stable organic solids forming stable, large crystallites with the ability to preserve favorable electrical properties upon bioconjugation. Lately, tremendous efforts have been made to use these bioconjugated semiconductors as… read more here.

Keywords: hydrogen bonded; hydrogen; organic semiconductors; binding sites ... See more keywords

Functional defect of variants in the adenosine triphosphate–binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX‐770)

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recommendations! Published in 2017 at "Hepatology"

DOI: 10.1002/hep.28929

Abstract: ABCB4 (MDR3) is an adenosine triphosphate (ATP)‐binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Variations in the ABCB4 gene are responsible for several biliary diseases, including… read more here.

Keywords: ivacaftor; ivacaftor 770; sites abcb4; potentiator ... See more keywords

GCNF regulates OCT4 expression through its interactions with nuclear receptor binding elements in NCCIT cells

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.26438

Abstract: We demonstrate that OCT4 expression is regulated by germ cell nuclear factor (GCNF) via its interactions with three nuclear receptor (NR) binding sites within OCT4 promoter conserved regions (CRs) in human embryonic carcinoma (EC) NCCIT… read more here.

Keywords: nccit cells; oct4 expression; binding sites; expression ... See more keywords
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Targeting BAX ubiquitin‐binding sites reveals that BAX activation is essential for its ubiquitin‐dependent degradation

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recommendations! Published in 2019 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.29505

Abstract: BAX is an important proapoptotic protein of the BCL‐2 family, and its stability is essential for the regulation of the mitochondrial apoptotic pathway. A previous study revealed that BAX could undergo degradation through the ubiquitin‐proteasome… read more here.

Keywords: bax; degradation; ubiquitin binding; binding sites ... See more keywords

Structural analysis of human G‐protein‐coupled receptor 17 ligand binding sites

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recommendations! Published in 2023 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.30388

Abstract: The human G protein coupled membrane receptor (GPR17), the sensor of brain damage, is identified as a biomarker for many neurological diseases. In human brain tissue, GPR17 exist in two isoforms, long and short. While… read more here.

Keywords: ligand binding; gpr17; receptor; binding sites ... See more keywords

Extension and refinement of the recognition motif for Toll‐like receptor 5 activation by flagellin

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recommendations! Published in 2018 at "Journal of Leukocyte Biology"

DOI: 10.1002/jlb.3vma0118-035r

Abstract: TLRs sense conserved and essential molecular components of microbes that invade multicellular organisms. The wide range of TLR agonists, differing in size and shape, is recognized either through a single or a pair of binding… read more here.

Keywords: recognition; binding sites; receptor; flagellin ... See more keywords

Prediction of Protein Metal Binding Sites Using Deep Neural Networks

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recommendations! Published in 2019 at "Molecular Informatics"

DOI: 10.1002/minf.201800169

Abstract: Metals have crucial roles for many physiological, pathological and diagnostic processes. Metal binding proteins or metalloproteins are important for metabolism functions. The proteins that reach the three‐dimensional structure by folding show which vital function is… read more here.

Keywords: metal binding; prediction protein; metal; binding sites ... See more keywords

Translating from Proteins to Ribonucleic Acids for Ligand‐binding Site Detection

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recommendations! Published in 2022 at "Molecular Informatics"

DOI: 10.1002/minf.202200059

Abstract: Identifying druggable ligand‐binding sites on the surface of the macromolecular targets is an important process in structure‐based drug discovery. Deep‐learning models have been shown to successfully predict ligand‐binding sites of proteins. As a step toward… read more here.

Keywords: acids ligand; ligand binding; translating proteins; ribonucleic acids ... See more keywords