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Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-03079-5
Abstract: DNA replication is an exceptional point of therapeutic intervention for many cancer types and several small molecules targeting DNA have been developed into clinically used antitumor agents. Many of these molecules are naturally occurring metabolites…
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Keywords:
binding small;
dna;
small molecules;
biolayer interferometry ... See more keywords
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Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00654
Abstract: The G-quadruplex (G4) forming C9orf72 GGGGCC (G4C2) expanded hexanucleotide repeat (EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Developing selective G4-binding ligands is challenging due to the conformational…
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Keywords:
quadruplex binding;
binding small;
c9orf72;
g4c2 ... See more keywords
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Published in 2022 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s0219720022400030
Abstract: In this paper, the authors present and describe, in detail, an original software-implemented numerical methodology used to determine the effect of mutations on binding to small chemical molecules, on the example of gefitinib, AMPPNP, CO-1686,…
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Keywords:
mutations binding;
effect mutations;
binding small;
small chemical ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134165
Abstract: G-quadruplexes (G4) are now extensively recognised as a peculiar non-canonical DNA geometry that plays a prime importance role in processes of biological relevance whose number is increasing continuously. The same is true for the less-studied…
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Keywords:
topology;
mechanistic details;
binding small;
geometry ... See more keywords