Biolayer interferometry provides a robust method for detecting DNA binding small molecules in microbial extracts
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-03079-5
Abstract: DNA replication is an exceptional point of therapeutic intervention for many cancer types and several small molecules targeting DNA have been developed into clinically used antitumor agents. Many of these molecules are naturally occurring metabolites… read more here.
Keywords: binding small; dna; small molecules; biolayer interferometry ... See more keywords
Insights into the Electrochemical CO2RR Performance and Binding of Small Molecules on Quaternary Thiospinels Ag2FeSn3S8 and Cu2FeSn3S8.
Sign Up to like & getrecommendations! Published in 2024 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.4c01584
Abstract: Using a mechanical synthesis method in the form of ball milling and an additional annealing step, a novel and accelerated route for the synthesis of the thiospinels toyohaite (Ag2FeSn3S8) and rhodostannite (Cu2FeSn3S8) was discovered. Both… read more here.
Keywords: electrochemical co2rr; co2rr performance; ag2fesn3s8 cu2fesn3s8; insights electrochemical ... See more keywords
Predicting the Binding of Small Molecules to Proteins through Invariant Representation of the Molecular Structure
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.4c00752
Abstract: We present a computational scheme for predicting the ligands that bind to a pocket of a known structure. It is based on the generation of a general abstract representation of the molecules, which is invariant… read more here.
Keywords: molecules proteins; structure; representation; binding small ... See more keywords
Selective C9orf72 G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00654
Abstract: The G-quadruplex (G4) forming C9orf72 GGGGCC (G4C2) expanded hexanucleotide repeat (EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Developing selective G4-binding ligands is challenging due to the conformational… read more here.
Keywords: quadruplex binding; binding small; c9orf72; g4c2 ... See more keywords
Analysis to determine the effect of mutations on binding to small chemical molecules
Sign Up to like & getrecommendations! Published in 2022 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s0219720022400030
Abstract: In this paper, the authors present and describe, in detail, an original software-implemented numerical methodology used to determine the effect of mutations on binding to small chemical molecules, on the example of gefitinib, AMPPNP, CO-1686,… read more here.
Keywords: mutations binding; effect mutations; binding small; small chemical ... See more keywords
Discriminating between Parallel, Anti-Parallel and Hybrid G-Quadruplexes: Mechanistic Details on Their Binding to Small Molecules
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134165
Abstract: G-quadruplexes (G4) are now extensively recognised as a peculiar non-canonical DNA geometry that plays a prime importance role in processes of biological relevance whose number is increasing continuously. The same is true for the less-studied… read more here.
Keywords: topology; mechanistic details; binding small; geometry ... See more keywords