Substrate Binding Stiffens Aspartate Aminotransferase by Altering the Enzyme Picosecond Vibrational Dynamics
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DOI: 10.1021/acsomega.0c01900
Abstract: Protein dynamics on various time scales from femtoseconds to milliseconds impacts biological function by driving proteins to conformations conducive to ligand binding and creating functional states in enzyme catalysis. Neutron vibrational spectroscopy carried out by… read more here.
Keywords: substrate binding; vibrational dynamics; binding stiffens; picosecond ... See more keywords