Peptidoglycan Isolation and Binding Studies with LysM-Type Pattern Recognition Receptors.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6859-6_1
Abstract: In the last decade, more and more plant receptors for complex carbohydrate structures have been described. However, studies on receptor binding to glycan ligands are often hampered due to the technical challenge to obtain pure… read more here.
Keywords: peptidoglycan isolation; studies lysm; lysm type; binding studies ... See more keywords
Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.11.016
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Antagonists for ATP‐activated P2X4 ion channel receptors are currently in the focus as novel drug targets, in particular for the treatment of neuropathic and inflammatory pain. We stably… read more here.
Keywords: radioligand binding; p2x4 receptor; p2x4; binding studies ... See more keywords
DNA binding studies of novel diazatruxenones analogs as potential anticancer agents: Synthesis, antitumor investigation, DNA binding, SAR and molecular modeling calculation.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104323
Abstract: A series of polycyclic skeleton of truxene and triazatruxene analogs has been synthesized and evaluated for antitumor and DNA binding activities. The synthesized structures were confirmed by different spectroscopic techniques such as IR, 1HNMR, 13CNMR,… read more here.
Keywords: molecular modeling; studies novel; dna; binding studies ... See more keywords
Synthesis, spectral characterization, and DNA binding studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff base 2-((1H-1,2,4-triazol-3-ylimino)methyl)-5-methoxyphenol
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.11.027
Abstract: Abstract A Schiff base ligand HL has been synthesized by the condensation of an equimolar amount of 2-hydroxy-4-methoxybenzaldehyde and 3-amino-1,2,4-triazole and characterized by elemental analysis, IR, 1H NMR, 13C NMR and ESI-mass spectrometry. The metal… read more here.
Keywords: metal; spectral characterization; metal complexes; binding studies ... See more keywords
Synthesis, characterization and DNA binding studies of rhenium(I) and (V) compounds with Schiff bases derived from 4-aminotetrahydropyran
Sign Up to like & getrecommendations! Published in 2017 at "Polyhedron"
DOI: 10.1016/j.poly.2017.01.037
Abstract: Abstract Herein, we report the synthesis, characterization and DNA binding studies of novel rhenium(I) and (V) complexes with Schiff bases derived from 4-aminotetrahydropyran. More specifically, the coordination reactions of 2-((tetrahydro-2H-pyran-4-ylimino)methyl)phenol (Htmp) with trans-[ReOCl3(PPh3)2], trans-[ReOBr3(PPh3)2] and… read more here.
Keywords: characterization dna; binding studies; spectroscopy; dna binding ... See more keywords
DNA/BSA binding studies of peripherally tetra substituted neutral azophenoxy zinc phthalocyanine
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DOI: 10.1016/j.poly.2019.114208
Abstract: Abstract A tetra substituted neutral zinc phthalocyanine (ZnPc-4) bearing 4-phenylazophenoxy group at the periphery had been prepared from zinc acetate dihydrate Zn(CH3COO)2·2H2O and 4-(phenylazophenoxy)phthalonitrile. The interaction of neutral metallophthalocyanine, ZnPc-4 with Calf Thymus (CT) DNA… read more here.
Keywords: tetra substituted; dna; substituted neutral; bsa binding ... See more keywords
Monitoring Protein Global and Local Parameters in Unfolding and Binding Studies: The Extended Applicability of the Diffusion Coefficient─Molecular Size Empirical Relations.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00481
Abstract: Protein unfolding and denaturation are main issues in biochemical and pharmaceutical research. Using a global parameter, the translational diffusion coefficient D, folded, unfolded, and intrinsically disordered proteins of a given molar mass M can be… read more here.
Keywords: local parameters; diffusion; empirical relations; diffusion coefficient ... See more keywords
Binding Studies of the Prodrug HAO472 to SARS-Cov-2 Nsp9 and Variants
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c07186
Abstract: SARS-CoV-2 (COVID-19) has infected over 219 million people and caused the death of over 4.55 million worldwide. In a previous screen of a natural product library against purified SARS-CoV-2 Nsp9 using a native mass spectrometry-based… read more here.
Keywords: cov nsp9; prodrug hao472; binding studies; studies prodrug ... See more keywords
Visible-light driven regioselective synthesis, characterization and binding studies of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines with DNA and BSA using biophysical and computational techniques
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-01037-4
Abstract: In recent times, fused azaheterocycles emerged as impressive therapeutic agents. Binding studies of such azaheterocycles with biomolecules is an important subject for pharmaceutical and biochemical studies aiming at the design and development of new drugs.… read more here.
Keywords: aroyl methyl; methyl dihydro; binding studies; thiazolo pyrimidines ... See more keywords
Stimuli-responsive spin crossover nanoparticles for drug delivery and DNA-binding studies.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt01509a
Abstract: Aminated silica hybrid, spin-crossover (SCO) nanoparticles (AmNPs) coupled with (S)-naproxen (NAP) were proposed for potential drug nanocarriers through drug release experiments at various pH values. DNA- and albumin-binding studies were also carried out using diverse… read more here.
Keywords: spin crossover; dna; drug; binding studies ... See more keywords
Inhibitor binding studies of Mycobacterium tuberculosis MraY (Rv2156c): Insights from molecular modeling, docking, and simulation studies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1526715
Abstract: Abstract Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (M.tb) or tubercule bacillus, and H37Rv is the most studied clinical strain. The recent development of resistance to existing drugs is a global health-care… read more here.
Keywords: inhibitor binding; mray rv2156c; tuberculosis; binding studies ... See more keywords