Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles
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DOI: 10.1002/open.202200131
Abstract: Abstract Optimizing linker design is important for ensuring efficient degradation activity of proteolysis‐targeting chimeras (PROTACs). Therefore, developing a straightforward synthetic approach that combines the protein‐of‐interest ligand (POI ligand) and the ligand for E3 ubiquitin ligase… read more here.
Keywords: protacs; synthesis; development rapid; solid phase ... See more keywords