Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs.
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DOI: 10.1021/acs.jmedchem.8b01281
Abstract: Binding of drugs to ocular melanin is a prominent biological phenomenon that affects the local pharmacokinetics and pharmacodynamics in the eye. In this work, we report on the development of in vitro and in silico… read more here.
Keywords: binding support; melanin; molecular drivers; melanin binding ... See more keywords