Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4–Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318085
Abstract: Background: Inappropriate activation and aggregation of platelets can lead to arterial thrombosis. Thrombin is the most potent platelet agonist that activates human platelets via two PARs (proteinase-activated receptors), PAR1 and PAR4. The aim is to… read more here.
Keywords: thrombin exosite; mediated platelet; platelet activation; binding thrombin ... See more keywords
Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910803
Abstract: Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both procoagulant and anticoagulant functions; therefore, it represents an attractive target for the developments of biomolecules with therapeutic potential.… read more here.
Keywords: structural dynamic; global structural; exosite binding; thrombin global ... See more keywords