Protein Binding in Translational Antimicrobial Development-Focus on Interspecies Differences
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DOI: 10.3390/antibiotics11070923
Abstract: Background/Introduction: Plasma protein binding (PPB) continues to be a key aspect of antibiotic development and clinical use. PPB is essential to understand several properties of drug candidates, including antimicrobial activity, drug-drug interaction, drug clearance, volume… read more here.
Keywords: protein binding; development; binding translational; ppb ... See more keywords
Interplay between Inter-Subunit Rotation of the Ribosome and Binding of Translational GTPases
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DOI: 10.3390/ijms24086878
Abstract: Translational G proteins, whose release from the ribosome is triggered by GTP hydrolysis, regulate protein synthesis. Concomitantly with binding and dissociation of protein factors, translation is accompanied by forward and reverse rotation between ribosomal subunits.… read more here.
Keywords: subunit rotation; inter subunit; binding translational; rotation ... See more keywords