Radiolabelling and preclinical characterization of 89Zr-Df-radiolabelled bispecific anti-PD-L1/TGF-βRII fusion protein bintrafusp alfa
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05251-0
Abstract: Τhis study aimed to optimize the 89Zr-radiolabelling of bintrafusp alfa investigational drug product and controls, and perform the in vitro and in vivo characterization of 89Zr-Df-bintrafusp alfa and 89Zr-Df-control radioconjugates. Bintrafusp alfa (anti-PD-L1 human IgG1… read more here.
Keywords: tgf rii; bintrafusp; 89zr bintrafusp; bintrafusp alfa ... See more keywords
Bullous pemphigoid secondary to bintrafusp alfa, a bifunctional fusion protein targeting TGF-beta and PD-L1
Sign Up to like & getrecommendations! Published in 2021 at "JAAD Case Reports"
DOI: 10.1016/j.jdcr.2021.04.027
Abstract: BP: bullous pemphigoid irAE: immune-related adverse events PD-1: programmed cell death-1 PD-L1: programmed cell death ligand-1 TGF-b: transforming growth factor beta Treg: T regulatory cell INTRODUCTION Immune checkpoint inhibitors targeting the programmed cell death-1 receptor… read more here.
Keywords: alfa bifunctional; bintrafusp alfa; bullous pemphigoid; beta ... See more keywords
Phase 2 trial of bintrafusp alfa as second-line therapy for patients with locally advanced/metastatic biliary tract cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000365
Abstract: BACKGROUND AIMS Biliary tract cancers are rare, heterogeneous cancers with poor prognosis. Bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII (a TGF-β "trap") fused to a human IgG1 mAb… read more here.
Keywords: locally advanced; biliary tract; tract cancers; bintrafusp alfa ... See more keywords
Immune correlates of clinical parameters in patients with HPV-associated malignancies treated with bintrafusp alfa
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004601
Abstract: Purpose Bintrafusp alfa is a bifunctional agent consisting of an anti-human PD-L1 antibody linked to two TGFβRII. It is designed to act both as a checkpoint inhibitor and to ‘trap’ TGFβ in the tumor microenvironment.… read more here.
Keywords: alfa; hpv associated; peripheral immunome; patients hpv ... See more keywords