Cardiac injury of the newborn mammalian heart accelerates cardiomyocyte terminal differentiation
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DOI: 10.1038/s41598-017-08947-2
Abstract: After birth cardiomyocytes undergo terminal differentiation, characterized by binucleation and centrosome disassembly, rendering the heart unable to regenerate. Yet, it has been suggested that newborn mammals regenerate their hearts after apical resection by cardiomyocyte proliferation.… read more here.
Keywords: newborn mammalian; terminal differentiation; heart; apical resection ... See more keywords
The response of fetal sheep cardiomyocytes to intralipid infusion
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DOI: 10.1152/physiol.2023.38.s1.5735063
Abstract: Introduction: The developing heart undergoes changes in metabolic substrates parallel with perinatal developmental stages. The preferred substrates for fetal hearts are carbohydrates, which transitions to a preference for fatty acids postnatally. The underdevelopment of lipid… read more here.
Keywords: binucleation; intralipid infusion; physiology; fatty acids ... See more keywords
Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation
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DOI: 10.1172/jci.insight.162124
Abstract: The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates during the first week of life. Postnatal regeneration is mainly driven by proliferation of preexisting cardiomyocytes and supported by proregenerative macrophages… read more here.
Keywords: regeneration; malat1 deficiency; binucleation; heart ... See more keywords