A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of radiation biology"
DOI: 10.1080/09553002.2021.1981556
Abstract: PURPOSE Exposure to high doses of ionizing radiation can result in hematopoietic acute radiation syndrome (H-ARS) and delayed effects of acute radiation exposure (DEARE). There is no radiation medical countermeasure approved by the U.S. Food… read more here.
Keywords: acute radiation; radiation exposure; mice; bio 300 ... See more keywords
Interspecies Comparison and Radiation Effect on Pharmacokinetics of BIO 300, a Nanosuspension of Genistein, after Different Routes of Administration in Mice and Non-Human Primates.
Sign Up to like & getrecommendations! Published in 2022 at "Radiation research"
DOI: 10.1667/rade-21-00114.1
Abstract: BIO 300, a suspension of synthetic genistein nanoparticles, is being developed for mitigating the delayed effects of acute radiation exposure (DEARE). The purpose of the current study was to characterize the pharmacokinetic (PK) profile of… read more here.
Keywords: mice; tbi bm2; radiation; tbi ... See more keywords
The Radioprotectant, BIO 300, Protects the Lungs from Total-Body Irradiation Injury in C57L/J Mice
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DOI: 10.1667/rade-22-00142.1
Abstract: Acute exposure to high dose radiation can cause acute radiation syndrome (ARS), a potentially life-threatening illness. Individuals that survive ARS are at risk of developing the delayed effects of acute radiation exposure, with the lungs… read more here.
Keywords: bio 300; lung; total body; radiation ... See more keywords
Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates
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DOI: 10.21203/rs.3.rs-1315244/v1
Abstract: BIO 300, a pharmaceutical formulation of genistein, is being developed as a radiation countermeasure to treat hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation exposure (DEARE). Several studies have affirmed its… read more here.
Keywords: bio 300; formulation; oral powder; 300 oral ... See more keywords