Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N‐desethylamodiaquine
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DOI: 10.1111/bcp.13148
Abstract: AIMS Oxidative bioactivation of amodiaquine (AQ) by cytochrome P450s to a reactive quinoneimine is considered as an important mechanism underlying its idiosyncratic hepatotoxicity. However, because internal exposure to its major metabolite N-desethylamodiaquine (DEAQ) is up… read more here.
Keywords: cytochrome; bioactivation; bioactivation amodiaquine; deaq ... See more keywords