Selective binding of a bioactive porphyrin-based photosensitizer to the G-quadruplex from the KRAS oncogene promoter.
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DOI: 10.1016/j.ijbiomac.2019.12.152
Abstract: BACKGROUND The G-quadruplex-forming sequence within the KRAS proto-oncogene P1 promoter is a promising target for anticancer therapy. Porphyrin derivatives are among the most rewarding G-quadruplex binders. They can also behave as photosensitizers. METHODS Three water-soluble,… read more here.
Keywords: binding bioactive; oncogene promoter; porphyrin based; bioactive porphyrin ... See more keywords