The Treatment of Large Bone Defects with Atrophic Nonunion by Bioactive Scaffolds Remodeling the Regeneration Microenvironment
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DOI: 10.1002/adhm.202500120
Abstract: Atrophic nonunion, a particularly challenging complication of diaphyseal bone fractures, arises from a deteriorated regenerative microenvironment characterized by insufficient vascularization and pathological accumulation of reactive oxygen species (ROS). To address this clinical challenge, a dualâfunction… read more here.
Keywords: bioactive scaffolds; atrophic nonunion; microenvironment; bone ... See more keywords
Design, synthetic approach, in silico molecular docking and antibacterial activity of quinazolin-2,4-dione hybrids bearing bioactive scaffolds
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DOI: 10.1039/d2ra06527d
Abstract: Antimicrobial resistance (AMR) is one of ten global public health threats facing humanity. This created the need to identify and develop effective inhibitors as antimicrobial agents. In this respect, quinazolin-2,4-dione hybrids bearing N-heterocyclic cores such… read more here.
Keywords: quinazolin dione; dione hybrids; dione; hybrids bearing ... See more keywords
The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation
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DOI: 10.3390/pharmaceutics12070602
Abstract: Porous scaffolds have been employed for decades in the biomedical field where researchers have been seeking to produce an environment which could approach one of the extracellular matrixes supporting cells in natural tissues. Such three-dimensional… read more here.
Keywords: overview porous; bioactive scaffolds; tissue regeneration; regeneration ... See more keywords
Creating a Microenvironment to Give Wings to Dental Pulp RegenerationâBioactive Scaffolds
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DOI: 10.3390/pharmaceutics15010158
Abstract: Dental pulp and periapical diseases make patients suffer from acute pain and economic loss. Although root canal therapies, as demonstrated through evidence-based medicine, can relieve symptoms and are commonly employed by dentists, it is still… read more here.
Keywords: pulp regeneration; dental pulp; pulp; medicine ... See more keywords