Increasing the bioactive space of peptide macrocycles by thioamide substitution††Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04671e
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DOI: 10.1039/c7sc04671e
Abstract: Thioamide substitution into macrocyclic peptides increases the conformational rigidity of the backbone resulting in enhanced biological activity and metabolic stability. read more here.
Keywords: space peptide; peptide macrocycles; bioactive space; thioamide substitution ... See more keywords