Synthesis and bioactivity of novel (γ-piperidono)dibenzo-33-aza-14-crown-3 ethers
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02512-7
Abstract: Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity… read more here.
Keywords: bioactivity; novel piperidono; synthesis bioactivity; piperidono dibenzo ... See more keywords
Design, Synthesis, and Bioactivity of Novel Bifunctional Small Molecules for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02130
Abstract: The abnormal phosphorylation of the τ-protein is a typical early pathological feature of Alzheimer’s disease (AD). The excessive phosphorylation of the τ-protein in the brain causes the formation of neurofibrillary tangles (NFTs) and increases the… read more here.
Keywords: design synthesis; alzheimer disease; synthesis bioactivity; bioactivity novel ... See more keywords