The role of ligand-binding assay and LC-MS in the bioanalysis of complex protein and oligonucleotide therapeutics.
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DOI: 10.4155/bio-2021-0009
Abstract: Ligand-binding assay (LBA) and LC-MS have been the preferred bioanalytical techniques for the quantitation and biotransformation assessment of various therapeutic modalities. This review provides an overview of the applications of LBA, LC-MS/MS and LC-HRMS for… read more here.
Keywords: binding assay; bioanalysis; oligonucleotide therapeutics; complex protein ... See more keywords