Chiral bioanalytical methods in bioequivalence studies of intravenous vs. oral formulations of ibuprofen.
Sign Up to like & getrecommendations! Published in 2020 at "Chirality"
DOI: 10.1002/chir.23258
Abstract: According to the Ibuprofen Product-Specific Bioequivalence Guidance of the European Medicines Agency, achiral bioanalytical methods are considered acceptable for demonstration of bioequivalence of ibuprofen-containing products. The aim of this investigation is to compare the bioequivalence… read more here.
Keywords: bioequivalence; sum enantiomers; ibuprofen; bioanalytical methods ... See more keywords
Recent developments of bioanalytical methods in determination of neurotransmitters in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.113079
Abstract: Neurotransmitters (NTs) constitute an important group of messenger molecules and their imbalance lead to various neurological disorders, making their analytical determination of great importance in both laboratory and clinical practice. Here we review the most… read more here.
Keywords: determination neurotransmitters; determination; recent developments; bioanalytical methods ... See more keywords
Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-PSMA PBD Antibody-Drug Conjugate.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01187
Abstract: Complex biotherapeutic modalities such as antibody-drug conjugates (ADC), present significant challenges for the comprehensive bioanalytical characterization of their pharmacokinetics (PK) and catabolism in both pre-clinical and clinical settings. Thus, the bioanalytical strategy for ADCs must… read more here.
Keywords: protein scaffold; bioanalytical methods; multifaceted bioanalytical; drug ... See more keywords
Characteristics, Properties and Analytical/Bioanalytical Methods of 5-Aminosalicylic Acid: A Review.
Sign Up to like & getrecommendations! Published in 2020 at "Critical reviews in analytical chemistry"
DOI: 10.1080/10408347.2020.1848516
Abstract: Five-aminosalicylic acid (5-ASA) is an anti-inflammatory drug indicated in the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Among the analytical methods of quantification of 5-ASA described in the literature, the… read more here.
Keywords: characteristics properties; bioanalytical methods; analytical bioanalytical; aminosalicylic acid ... See more keywords
Bioanalytical Methods for Poly(ADP-Ribose) Polymerase Inhibitor Quantification: A Review for Therapeutic Drug Monitoring
Sign Up to like & getrecommendations! Published in 2023 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001081
Abstract: Background: Therapeutic drug monitoring (TDM) of poly(ADP-ribose) polymerase inhibitors (PARPis) is an exploratory practice aimed at improving the quality of treatment through personalized therapy. Currently, there are 4 European Medicines Agency-approved and US Food and… read more here.
Keywords: poly adp; quantification; bioanalytical methods; therapeutic drug ... See more keywords
Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from Holothuria fuscopunctata, a Novel Anticoagulant Candidate, in Rats by Bioanalytical Methods
Sign Up to like & getrecommendations! Published in 2021 at "Marine Drugs"
DOI: 10.3390/md19040212
Abstract: dHG-5 (Mw 5.3 kD) is a depolymerized glycosaminoglycan from sea cucumber Holothuria fuscopunctata. As a selective inhibitor of intrinsic Xase (iXase), preclinical study showed it was a promising anticoagulant candidate without obvious bleeding risk. In… read more here.
Keywords: holothuria fuscopunctata; bioanalytical methods; depolymerized glycosaminoglycan; dhg ... See more keywords
Bioanalytical methods for the quantification of cis-permethrin and trans-permethrin in biological samples.
Sign Up to like & getrecommendations! Published in 2017 at "Bioanalysis"
DOI: 10.4155/bio-2017-0157
Abstract: Permethrin (PERM) is a synthetic type I pyrethroidal pesticide with broad-spectrum insecticide activity. This compound has been widely used over the past 50 years in agriculture, indoor pest control products, lotions or shampoos for head… read more here.
Keywords: methods quantification; bioanalytical methods; cis permethrin; quantification cis ... See more keywords