Enhancing Bioavailability of Fertilizer through Amyloid-Like Protein Coating.
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DOI: 10.1002/adma.202300829
Abstract: Foliar fertilization acts as a ubiquitous component of conventional crop production because the nutrients can be absorbed more quickly than soil fertilizers, which brings considerable economic and ecological costs. Due to droplets rebounding and splashing… read more here.
Keywords: fertilizer; bioavailability fertilizer; amyloid like; bioavailability ... See more keywords
Cannabidiol‐Loaded Poly Lactic‐Co‐Glycolic Acid Nanoparticles with Improved Bioavailability as a Potential for Osteoarthritis Therapeutic
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DOI: 10.1002/cbic.202200698
Abstract: Cannabidiol (CBD) is a non‐intoxicating cannabinoid from cannabis sativa that has demonstrated efficacious against inflammation, which can be considered as a potential drug for arthritis treatment. However, the poor solubility and low bioavailability limit its… read more here.
Keywords: cbd plga; cannabidiol; bioavailability; plga nps ... See more keywords
A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14C‐Microtracer Approach
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DOI: 10.1002/cpdd.1109
Abstract: Zimlovisertib (PF‐06650833) is a selective, reversible inhibitor of interleukin‐1 receptor‐associated kinase 4 (IRAK4) with anti‐inflammatory effects. This phase 1, open‐label, fixed‐sequence, two‐period, single‐dose study aimed to evaluate the mass balance and excretion rate of zimlovisertib… read more here.
Keywords: zimlovisertib healthy; zimlovisertib; bioavailability; mass balance ... See more keywords
Comparative Bioavailability of a Single Dose of Trametinib (TMT212) Containing 9% vs 11% Dimethyl Sulfoxide in Randomized Healthy Volunteers to Assess Long‐Term Storage at Room Temperature
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DOI: 10.1002/cpdd.1129
Abstract: Storage of trametinib tablets outside of 2‐8°C protected from moisture may lead to loss of dimethyl sulfoxide (DMSO) and adversely impact trametinib bioavailability. In this open‐label, phase 1, single‐dose, randomized, 2‐treatment, 2‐period crossover study in… read more here.
Keywords: single dose; healthy volunteers; bioavailability; trametinib ... See more keywords
Bioequivalence and Relative Bioavailability Studies to Assess a New Acalabrutinib Formulation That Enables Coadministration With Proton‐Pump Inhibitors
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DOI: 10.1002/cpdd.1153
Abstract: Acalabrutinib is a Bruton tyrosine kinase (BTK) inhibitor approved to treat adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or previously treated mantle cell lymphoma. As the bioavailability of the acalabrutinib capsule (AC) depends on… read more here.
Keywords: proton pump; coadministration proton; bioavailability; pump inhibitors ... See more keywords
Pharmacokinetics, Bioavailability, and Swallowing Safety With Riluzole Oral Film
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DOI: 10.1002/cpdd.1168
Abstract: Dysphagia is highly prevalent in patients with amyotrophic lateral sclerosis (ALS). Riluzole is a US Food and Drug Administration‐approved treatment for ALS. Riluzole oral film (ROF; Exservan™) contains riluzole in a polymer‐based film matrix. The… read more here.
Keywords: safety; bioavailability; oral film; rof ... See more keywords
Edaravone Administered Orally and Via Nasogastric Tube in Healthy Adults: A Comparative Bioavailability Phase 1 Study
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DOI: 10.1002/cpdd.1175
Abstract: Intravenous edaravone is used to treat patients with amyotrophic lateral sclerosis. This randomized, open‐label, two‐way crossover, single‐dose phase 1 study compared the relative bioavailability of a newly developed edaravone oral suspension when administered orally and… read more here.
Keywords: orally via; bioavailability; phase study; tube ... See more keywords
Effect of a High‐Fat Meal on Single‐Dose Rencofilstat (CRV431) Oral Bioavailability in Healthy Human Subjects
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DOI: 10.1002/cpdd.1179
Abstract: Rencofilstat (RCF) is a novel cyclophilin inhibitor under development for the treatment of nonalcoholic steatohepatitis and hepatocellular carcinoma. This phase 1, randomized, open‐label study in healthy participants assessed the relative bioavailability of a single dose… read more here.
Keywords: single dose; fat meal; high fat; bioavailability ... See more keywords
Effects of Tablet Formulation, Food, or Gastric pH on the Bioavailability of Asundexian
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DOI: 10.1002/cpdd.1207
Abstract: Absolute bioavailability (F) and the impact of gastric pH, tablet formulation, and food on the pharmacokinetics and safety of asundexian, an oral factor XIa inhibitor, was assessed in healthy White men aged 18–45 years in… read more here.
Keywords: tablet formulation; formulation; food; bioavailability ... See more keywords
A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Savolitinib in Healthy Male Volunteers
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DOI: 10.1002/cpdd.1224
Abstract: Savolitinib is an oral MET (hepatocyte growth factor receptor) tyrosine kinase inhibitor, with demonstrated preliminary efficacy in several cancer types. Previous pharmacokinetics assessments showed that savolitinib is rapidly absorbed but there are limited data on… read more here.
Keywords: metabolism; bioavailability; savolitinib; bioavailability absorption ... See more keywords
The Oral Bioavailability and Effect of Various Gastric Conditions on the Pharmacokinetics of Dersimelagon in Healthy Adult Volunteers
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DOI: 10.1002/cpdd.1235
Abstract: Dersimelagon is a novel orally administered selective agonist for melanocortin receptor 1 being investigated for the treatment of erythropoietic protoporphyria, X‐linked protoporphyria, and diffuse cutaneous systemic sclerosis. In this open‐label, multicenter, randomized, two‐cohort, sequential crossover… read more here.
Keywords: oral bioavailability; various gastric; bioavailability; effect various ... See more keywords