Enhancement of In Vivo Efficacy and Oral Bioavailability of Aripiprazole with Solid Lipid Nanoparticles
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DOI: 10.1208/s12249-017-0944-5
Abstract: Aripiprazole (ARP), a second-generation or atypical antipsychotic, is poorly soluble and undergoes extensive hepatic metabolism and P-glycoprotein efflux which lead to reduced in vivo efficacy and increased dose-related side effects. To enhance in vivo efficacy… read more here.
Keywords: vivo efficacy; bioavailability aripiprazole; solid lipid; lipid nanoparticles ... See more keywords