Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor.
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DOI: 10.1021/acs.jmedchem.0c02093
Abstract: The receptor tyrosine kinase Axl plays important roles in promoting cancer progression, metastasis, and drug resistance and has been identified as a promising target for anticancer therapeutics. We used molecular modeling-assisted structural optimization starting with… read more here.
Keywords: potent orally; orally bioavailable; axl; bioavailable axl ... See more keywords