Discovery of Selenium-Containing Derivatives as Potent and Orally Bioavailable GLP-1R Agonists.
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DOI: 10.1021/acs.jmedchem.4c02616
Abstract: Glucagon-like peptide-1 receptor (GLP-1R) is a well-established target for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The development of orally bioavailable and long-acting small-molecule GLP-1R agonists is a pursuit in both academia… read more here.
Keywords: glp; orally bioavailable; selenium containing; bioavailable glp ... See more keywords