Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
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DOI: 10.1021/acs.jmedchem.0c01836
Abstract: To develop potent and orally bioavailable melatonin receptor (MT1 and MT2) agonists, a novel series of 5-6-5 tricyclic derivatives was designed, synthesized, and evaluated. The synthesized indeno[5,4-d][1,3]oxazole, cyclopenta[c]pyrazolo[1,5-a]pyridine, indeno[5,4-d][1,3]thiazole, and cyclopenta[e]indazole derivatives showed potent binding… read more here.
Keywords: potent orally; orally bioavailable; bioavailable melatonin; melatonin receptor ... See more keywords