Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a key off-target activity.
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DOI: 10.1021/acs.jmedchem.9b01585
Abstract: Optimisation of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for the class III… read more here.
Keywords: orally bioavailable; pi3k; optimization orally; compound ... See more keywords