Discovery of Orally Bioavailable SOS1 Inhibitors for Suppressing KRAS-Driven Carcinoma.
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DOI: 10.1021/acs.jmedchem.2c00986
Abstract: The interaction between son of sevenless 1 (SOS1) gene and Kirsten rat sarcoma viral oncogene (KRAS) is crucial for activating signals of proliferation and survival in a range of cancers. We previously discovered compound 40a… read more here.
Keywords: bioavailable sos1; orally bioavailable; kras driven; suppressing kras ... See more keywords