Constructing Spatiotemporally Controllable Biocatalytic Cascade in RBC Nanovesicles for Precise Tumor Therapy Based on Reversibly Induced Glucose Oxidase-Magnetoferritin Dimers.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300205
Abstract: Chemodynamic therapy is a promising tumor treatment strategy. However, it remains a great challenge to overcome the unavoidable off-target damage towards normal tissues. In our work we discover that magnetoferritin (M-HFn, biomimic peroxidase) can form… read more here.
Keywords: controllable biocatalytic; cascade; spatiotemporally controllable; therapy ... See more keywords
Development of an aminotransferase-driven biocatalytic cascade for deracemization of d,l-phosphinothricin.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28432
Abstract: 2-oxo-4-[(hydroxy)(methyl)phosphinoyl]butyric acid (PPO) is the essential precursor keto acid for the asymmetric biosynthesis of herbicide l-phosphinothricin (l-PPT). Developing a biocatalytic cascade for PPO production with high efficiency and low cost is highly desired. Herein, a… read more here.
Keywords: ppo; cascade; biocatalytic cascade; aminotransferase driven ... See more keywords
A Biocatalytic Cascade Reaction to Access a Valuable Long‐Chain ω‐Hydroxy Fatty Acid
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DOI: 10.1002/cctc.202000745
Abstract: Environmentally‐friendly processes for the manufacturing of valuable industrial compounds like ω‐hydroxy fatty acids (ω‐OHFAs) are highly desirable. Herein, we present such an approach by establishing a two‐step enzymatic cascade reaction for the production of 2,15,16‐trihydroxy… read more here.
Keywords: biocatalytic cascade; acid; hydroxy fatty; cascade reaction ... See more keywords
Coupled Natural Fusion Enzymes in a Novel Biocatalytic Cascade Convert Fatty Acids to Amines
Sign Up to like & getrecommendations! Published in 2022 at "ACS Catalysis"
DOI: 10.1021/acscatal.2c02954
Abstract: Tambjamine YP1 is a pyrrole-containing natural product. Analysis of the enzymes encoded in the Pseudoalteromonas tunicata “tam” biosynthetic gene cluster (BGC) identified a unique di-domain biocatalyst (PtTamH). Sequence and bioinformatic analysis predicts that PtTamH comprises… read more here.
Keywords: pttamh; domain; biocatalytic cascade; pttama ... See more keywords
Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C–C Bond-Forming α-Oxoamine Synthase
Sign Up to like & getrecommendations! Published in 2023 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.3c00243
Abstract: We report a chemo-biocatalytic cascade for the synthesis of substituted pyrroles, driven by the action of an irreversible, thermostable, pyridoxal 5′-phosphate (PLP)-dependent, C–C bond-forming biocatalyst (ThAOS). The ThAOS catalyzes the Claisen-like condensation between various amino… read more here.
Keywords: chemo biocatalytic; versatile chemo; biocatalytic cascade; bond forming ... See more keywords
Highly efficient biocatalytic cascade for the diversity-oriented synthesis of complex blood group Sdaantigens
Sign Up to like & getrecommendations! Published in 2020 at "Green Chemistry"
DOI: 10.1039/d0gc02971h
Abstract: Highly efficient multienzyme cascade synthesis of 15 naturally occurring complex Sdaantigens. read more here.
Keywords: synthesis; efficient biocatalytic; cascade; cascade diversity ... See more keywords
Design of a biocatalytic cascade for the enzymatic sulfation of unsulfated chondroitin with in situ generation of PAPS
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1099924
Abstract: Sulfation of molecules in living organisms is a process that plays a key role in their functionality. In mammals, the sulfation of polysaccharides (glycosaminoglycans) that form the proteoglycans present in the extracellular matrix is particularly… read more here.
Keywords: sulfation; generation; biocatalytic cascade; enzymatic sulfation ... See more keywords