Efficient chemoenzymatic synthesis of α-aryl aldehydes as intermediates in C-C bond forming biocatalytic cascades.
Sign Up to like & getrecommendations! Published in 2022 at "ACS catalysis"
DOI: 10.1021/acscatal.2c02369
Abstract: Multi-enzyme biocatalytic cascades are emerging as practical routes for the synthesis of complex bioactive molecules. However, the relative sparsity of water-stable carbon electrophiles limits the synthetic complexity of molecules made from such cascades. Here, we… read more here.
Keywords: biocatalytic cascades; aryl aldehydes; bond forming; synthesis ... See more keywords
Biocatalytic Cascades toward Iminosugar Scaffolds Reveal Promiscuous Activity of Shikimate Dehydrogenases
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DOI: 10.1021/acscentsci.2c01169
Abstract: Iminosugar scaffolds are highly sought-after pharmaceutical targets, but their chemical synthesis is lengthy and can suffer from poor scalability and purification. Here we report protecting-group-free chemoenzymatic and biocatalytic cascades to synthesize iminosugars from sugar-derived aminopolyols… read more here.
Keywords: shikimate dehydrogenases; cascades toward; biocatalytic cascades; iminosugar scaffolds ... See more keywords
Controlling biocatalytic cascades with enzyme–DNA dynamic networks
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DOI: 10.1038/s41929-020-00524-7
Abstract: Cellular transformations, such as gene expression or temporal protein activities, are controlled by complex stimuli-responsive network circuitries regulated by enzymes, metabolites or transcription factors. Inspired by nature, extensive research efforts are directed to mimic these… read more here.
Keywords: network; biocatalytic cascades; cascades enzyme; dynamic networks ... See more keywords
Photo-Biocatalytic Cascades for the Synthesis of Volatile Sulfur Compounds and Chemical Building Blocks
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DOI: 10.1055/s-0039-1690784
Abstract: Biocatalysis is a branch of catalysis that exploits enzymes to perform highly stereoselective chemical transformations under mild and sustainable conditions. This Synpact highlights how biocatalysis can be used in the synthesis of chiral 1,3-mercaptoalkanols, an… read more here.
Keywords: volatile sulfur; sulfur compounds; photo biocatalytic; biocatalytic cascades ... See more keywords
Dissipative biocatalytic cascades and gated transient biocatalytic cascades driven by nucleic acid networks
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn3534
Abstract: Living systems consist of complex transient cellular networks guiding structural, catalytic, and switchable functions driven by auxiliary triggers, such as chemical or light energy inputs. We introduce two different transient, dissipative, biocatalytic cascades, the coupled… read more here.
Keywords: transient biocatalytic; biocatalytic cascades; dissipative biocatalytic; nucleic acid ... See more keywords