LAUSR

Biocatalytic synthesis of 2′‐deoxynucleotide 5′‐triphosphates from bacterial genomic DNA: Proof of principle

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2 Published in 2023 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.28374

Abstract: 2′‐deoxynucleoside 5′‐triphosphates (dNTPs) are the building blocks of DNA and are key reagents which are incorporated by polymerase enzymes during nucleic acid amplification techniques, such as polymerase chain reaction (PCR). These techniques are of high… read more here.

Keywords: proof principle; dna; genomic dna; bacterial genomic ... See more keywords

Biocatalytic synthesis of seleno-, thio- and chloro-nucleobase modified nucleosides by thermostable nucleoside phosphorylases

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0 Published in 2019 at "Catalysis Communications"

DOI: 10.1016/j.catcom.2018.12.004

Abstract: Abstract Selenium-containing nucleosides are the building blocks of the Se-nucleic acids useful for structure-and-function study, drug discovery and for targeting nucleic acids and their protein complexes. However, chemical synthesis of these Se-containing nucleosides is labor-intensive… read more here.

Keywords: modified nucleosides; biocatalytic synthesis; synthesis; thermostable nucleoside ... See more keywords

Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System

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2 Published in 2020 at "ACS Catalysis"

DOI: 10.1021/acscatal.0c00929

Abstract: The biocatalytic synthesis of amides from carboxylic acids and primary amines in aqueous media can be achieved using the ATP-dependent amide bond synthetase McbA, via an adenylate intermediate, using only 1.5 equiv of the amine… read more here.

Keywords: biocatalytic synthesis; mcba; bond synthetase; acid ... See more keywords

Biocatalytic synthesis of fungal β-glucans

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0 Published in 2018 at "Catalysts"

DOI: 10.3390/catal8070274

Abstract: Glucans are the dominant polysaccharide constituents of fungal cell walls. Remarkably, these major bioactive polysaccharides account for the beneficial effects that have been observed by many mushr ... read more here.

Keywords: biocatalytic synthesis; synthesis fungal; fungal glucans;

Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations

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0 Published in 2020 at "Molecules"

DOI: 10.3390/molecules25040934

Abstract: The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in transglycosylation reactions… read more here.

Keywords: thermodynamic calculations; dihalogenated nucleoside; biocatalytic synthesis; efficient biocatalytic ... See more keywords