Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets
Sign Up to like & getrecommendations! Published in 2020 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.15675.1
Abstract: Targeting the interaction of proteins with weak binding affinities or low solubility represents a particular challenge for drug screening. The NanoLuc â ® Binary Technology (NanoBiT â ®) was originally developed to detect protein-protein interactions… read more here.
Keywords: protein; biochemical assay; protein protein; cell free ... See more keywords
Novel carbon skeletons activate human NicotinAMide Phosphoribosyl Transferase (NAMPT) enzyme in biochemical assay
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DOI: 10.1371/journal.pone.0283428
Abstract: Nicotinamide adenine dinucleotide (NAD) is a central molecule in cellular metabolism that has been implicated in human health, the aging process, and an array of human diseases. NAD is well known as an electron storage… read more here.
Keywords: carbon skeletons; carbon; novel carbon; nampt enzyme ... See more keywords