Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01305
Abstract: Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs containing 7-substituted 7-deazapurine moiety. We… read more here.
Keywords: cdns; design synthesis; dinucleotide; synthesis biochemical ... See more keywords
Biochemical and biological validations of a faecal glucocorticoid metabolite assay in mandrills (Mandrillus sphinx)
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DOI: 10.1093/conphys/coz032
Abstract: Stress is a major factor when releasing endangered species into the wild but is often overlooked. We explored methods to measure stress non-invasively that can be applied to rehabilitated rescued mandrills following release into the… read more here.
Keywords: validations faecal; glucocorticoid metabolite; biochemical biological; biological validations ... See more keywords