Biochemical, pharmacological and structural characterization of BmooMP-I, a new P-I metalloproteinase from Bothrops moojeni venom.
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DOI: 10.1016/j.biochi.2020.09.001
Abstract: Snakebite envenoming is still a worrying health problem in countries under development, being recognized as a neglected disease by the World Health Organization. In Latin America, snakes from the genus Bothrops are widely spread and… read more here.
Keywords: bmoomp new; pharmacological structural; moojeni venom; metalloproteinase ... See more keywords
Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives.
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DOI: 10.1016/j.ejmech.2020.112145
Abstract: Morphine and its derivatives play inevitably important role in the μ-opioid receptor (MOR) targeted antinociception. A structure-activity relationship study is presented for novel and known orvinol and thevinol derivatives with varying 3-O, 6-O, 17-N and… read more here.
Keywords: orvinol thevinol; synthesis biochemical; thevinol derivatives; biochemical pharmacological ... See more keywords