Biochemical and structural insights into an allelic variant causing the lysosomal storage disorder – aspartylglucosaminuria
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13190
Abstract: Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by defects of the hydrolase glycosylasparaginase (GA). Previously, we showed that a Canadian AGU mutation disrupts an obligatory intramolecular autoprocessing with the enzyme trapped as an inactive… read more here.
Keywords: lysosomal storage; storage disorder; biochemical structural; structural insights ... See more keywords
Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14360
Abstract: Mycobacterium abscessus is a pathogenic non-tuberculous mycobacterium that possesses an intrinsic drug-resistance profile. Several N-acetyltransferases mediate drug resistance and/or participate in M. abscessus virulence. Mining the M. abscessus genome has revealed genes encoding additional N-acetyltransferases… read more here.
Keywords: mab 4324c; mycobacterium abscessus; abscessus; biochemical structural ... See more keywords
Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200576
Abstract: Transient receptor potential (TRP) channels have important roles in environmental sensing in animals. Human TRP subfamily A member 1 (TRPA1) is responsible for sensing allyl isothiocyanate (AITC) and other electrophilic sensory irritants. TRP subfamily vanilloid… read more here.
Keywords: transient receptor; biochemical structural; receptor potential; hydroxylation ... See more keywords
Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4654
Abstract: Methylenetetrahydrofolate reductase (MTHFR) is a key metabolic enzyme in colonization and virulence of Neisseria meningitidis, a causative agent of meningococcal diseases. Here, the biochemical and structural properties of MTHFR from a virulent strain of N.… read more here.
Keywords: ch2 h4folate; biochemical structural; methylenetetrahydrofolate reductase;
Thermal and dynamic mechanical characterization of miscanthus stem fragments: Effects of genotypes, positions along the stem and their relation with biochemical and structural characteristics
Sign Up to like & getrecommendations! Published in 2020 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2020.112863
Abstract: Abstract The thermal and dynamic mechanical properties of miscanthus stem fragments and differences between genotypes and positions along the stem are studied in relation with their biochemical and structural characteristics. The starting degradation temperature does… read more here.
Keywords: stem fragments; structural characteristics; along stem; biochemical structural ... See more keywords
Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.06.017
Abstract: Arabinoxylans are constituents of the human diet. Although not utilizable by the human host, they can be fermented by colonic bacteria. The arabinoxylan backbone is decorated with arabinose side chains that may be substituted with… read more here.
Keywords: analyses two; bifae1a; structural analyses; bacteroides intestinalis ... See more keywords
Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00673
Abstract: Tautomycetin (TTN) is a polyketide natural product featuring a terminal alkene. Functional characterization of the genes within the ttn gene cluster from Streptomyces griseochromogenes established the biosynthesis of the TTN polyketide backbone, its dialkylmaleic anhydride… read more here.
Keywords: ttnd; dependent decarboxylase; ttn; biochemical structural ... See more keywords
Correlating Biochemical and Structural Changes in the Brain with Clinical Features in COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00164
Abstract: With emerging reports of the deleterious effects of SARS-CoV-2 reflecting as neurological deficits in COVID-19, the biochemical and morphological changes it casts on the brain are also being investigated. This is an important niche of… read more here.
Keywords: correlating biochemical; biochemical structural; changes brain; structural changes ... See more keywords
Biochemical and structural characterization of tomato polyphenol oxidases provide novel insights into their substrate specificity
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-39687-0
Abstract: Polyphenol oxidases (PPOs) contain the structurally similar enzymes tyrosinases (TYRs) and catechol oxidases (COs). Two cDNAs encoding pro-PPOs from tomato (Solanum lycopersicum) were cloned and heterologously expressed in Escherichia coli. The two pro-PPOs (SlPPO1-2) differ… read more here.
Keywords: polyphenol oxidases; tomato; kcat; polyphenol ... See more keywords
Biochemical and structural insights into the cytochrome P450 reductase from Candida tropicalis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56516-6
Abstract: Cytochrome P450 reductases (CPRs) are diflavin oxidoreductases that supply electrons to type II cytochrome P450 monooxygenases (CYPs). In addition, it can also reduce other proteins and molecules, including cytochrome c, ferricyanide, and different drugs. Although… read more here.
Keywords: structural insights; biochemical structural; insights cytochrome; cytochrome p450 ... See more keywords
Biochemical and structural differences between C3 cotyledons and C4 leaves in species of Salsoloideae (Chenopodiaceae)
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-20388-w
Abstract: C4 plants had evolved from C3 ancestors in at least more than 60 independent lineages of angiosperms, most probably in response to decreasing levels of atmospheric CO2 and environmental conditions promoting photorespiration. Salsola, Petrosimonia, and… read more here.
Keywords: cotyledons leaves; differences cotyledons; leaves species; species salsoloideae ... See more keywords