Atmospheric Plasma Deposition of Methacrylate Layers Containing Catechol/Quinone Groups: An Alternative to Polydopamine Bioconjugation for Biomedical Applications
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201701059
Abstract: Bioconjugation of enzymes on coatings based on polydopamine (PDA) layers is an appealing approach to control biological responses on biomedical implant surfaces. As alternative to PDA wet deposition, a fast, solvent-free, and dynamic deposition approach… read more here.
Keywords: quinone groups; bioconjugation; plasma; deposition ... See more keywords
Advances in targeted nanotherapeutics: From bioconjugation to biomimicry
Sign Up to like & getrecommendations! Published in 2018 at "Nano Research"
DOI: 10.1007/s12274-018-2083-z
Abstract: Since the emergence of cancer nanomedicine, researchers have had intense interest in developing nanoparticles (NPs) that can specifically target diseased sites while avoiding healthy tissue to mitigate the off-target effects seen with conventional treatments like… read more here.
Keywords: bioconjugation; bioconjugation biomimicry; advances targeted; nanotherapeutics bioconjugation ... See more keywords
Expeditious and scalable preparation of a Li−Thiele reagent for amine-based bioconjugation
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.06.019
Abstract: Abstract Chemoselective amine bioconjugation has long been a challenge for native protein modification. Inspired by Thiele’s seminal discovery, Li and co-workers recently developed an ortho-phthalaldehyde (OPA) based reagent for labeling the amino group of a… read more here.
Keywords: reagent; bioconjugation; scalable preparation; amine ... See more keywords
Microfluidic Droplet-SERS Platform for Single-Cell Cytokine Analysis via a Cell Surface Bioconjugation Strategy.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01249
Abstract: A microfluidic-based surface-enhanced Raman scattering (SERS) platform for analyzing cytokines secreted by single cells is reported based on the elaborate bioconjugation of the immuno-sandwich complex on the probed cell surface. This platform integrates the dual… read more here.
Keywords: cell; cell surface; microfluidic droplet; surface ... See more keywords
Pentafulvene-Maleimide Cycloaddition for Bioorthogonal Ligation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00287
Abstract: The applications of bioconjugation chemistry are rapidly expanding, and the addition of new strategies to the bioconjugation and ligation toolbox will further advance progress in this field. Herein, we present a detailed study of the… read more here.
Keywords: bioconjugation; cycloaddition; chemistry; ligation ... See more keywords
Dual-Boronic Acid Reagents That Combine Dynamic and Covalent Bioconjugation.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00508
Abstract: Boronic acids and boronate esters find appreciable use in chemical biology. Molecules containing orthogonal boronic acid pairs can be utilized for sequential metal-catalyzed cross-couplings for facile preparation of complex bioconjugates including protein-protein conjugates. In this… read more here.
Keywords: acid reagents; bioconjugation; boronic acid; reagents combine ... See more keywords
Bioconjugation of Au25 Nanocluster to Monoclonal Antibody at Tryptophan.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.3c00069
Abstract: We report the first bioconjugation of Au25 nanocluster to a monoclonal antibody at scarcely exposed tryptophan (Trp) residues toward the development of high-resolution probes for cryogenic electron microscopy (cryo-EM) and tomography (cryo-ET). To achieve this,… read more here.
Keywords: bioconjugation; nanocluster monoclonal; bioconjugation au25; au25 nanocluster ... See more keywords
Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00740
Abstract: Chemical proteomics is a powerful technology that can be used in the studies of the functions of uncharacterized proteins in the human proteome. It relies on a suitable bioconjugation strategy for protein labeling. This could… read more here.
Keywords: protein labeling; bioconjugation protein; induced bioconjugation; bioconjugation ... See more keywords
Enzyme Activated Gold Nanoparticles for Versatile Site-Selective Bioconjugation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c11678
Abstract: A new enzymatic method is reported for constructing protein- and DNA-AuNP conjugates. The strategy relies on the initial functionalization of AuNPs with phenols, followed by activation with the enzyme tyrosinase. Using an oxidative coupling reaction,… read more here.
Keywords: bioconjugation; activated gold; enzyme activated; aunps ... See more keywords
Mechano-bioconjugation Strategy Empowering Fusion Protein Therapeutics with Aggregation Resistance, Prolonged Circulation, and Enhanced Antitumor Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06532
Abstract: Bioconjugation is a powerful protein modification strategy to improve protein properties. Herein, we report mechano-bioconjugation as a novel approach to empower fusion protein therapeutics and demonstrate its utility by a protein heterocatenane (cat-IFN-ABD) containing interferon-α2b… read more here.
Keywords: fusion protein; bioconjugation; ifn abd; mechano bioconjugation ... See more keywords
A Chemoselective Rapid Azo-Coupling Reaction (CRACR) for Unclickable Bioconjugation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05125
Abstract: Chemoselective modification of complex biomolecules has become a cornerstone of chemical biology. Despite the exciting developments of the past two decades, the demand for new chemoselective reactions with unique abilities, and those compatible with existing… read more here.
Keywords: bioconjugation; azo coupling; chemoselective rapid; coupling reaction ... See more keywords