Biocompatible mucoadhesive nanoparticles for brain targeting of ropinirole hydrochloride: Formulations, radiolabeling and biodistribution.
Sign Up to like & getrecommendations! Published in 2022 at "Biopolymers"
DOI: 10.1002/bip.23489
Abstract: Two nanoformulations with mucoadhesive properties and brain-targeting mechanisms were designed to deliver the anti-Parkinson's drug, ropinirole hydrochloride (RH). In the first formulation, RH and the amphiphilic block copolymer methoxy poly(ethylene glycol)-b-poly(caprolactone) were assembled in a… read more here.
Keywords: administration; brain targeting; biodistribution; ropinirole hydrochloride ... See more keywords
Nonclinical safety assessment of repeated administration and biodistribution of ChAd3‐EBO‐Z Ebola candidate vaccine
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3941
Abstract: ChAd3‐EBO‐Z is an investigational adenovirus‐based vaccine for the prevention of Ebola virus disease. Two nonclinical studies were performed to evaluate the biodistribution, local tolerance and potential local and systemic toxic effects of this vaccine. In… read more here.
Keywords: safety assessment; biodistribution; assessment repeated; chad3 ebo ... See more keywords
A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived extracellular vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12280
Abstract: Abstract Mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (sEVs) show therapeutic potential in multiple disease models, including kidney injury. Clinical translation of sEVs requires further preclinical and regulatory developments, including elucidation of the biodistribution and… read more here.
Keywords: biodistribution; extracellular vesicles; kidney; model ... See more keywords
Improved accuracy of the biodistribution and internal radiation dosimetry of 13 N-ammonia using a total-body PET/CT scanner.
Sign Up to like & getrecommendations! Published in 2023 at "Medical physics"
DOI: 10.1002/mp.16450
Abstract: BACKGROUND Conventional short-axis PET typically utilizes multi-bed multi-pass acquisition to produce quantitative whole-body dynamic images and cannot record all the uptake information simultaneously, resulting in errors when fitting the time-activity curves (TACs) and calculating radiation… read more here.
Keywords: biodistribution; axis pet; short axis; radiation ... See more keywords
In Vivo Bacteriophage Biodistribution.
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DOI: 10.1007/978-1-4939-7395-8_11
Abstract: At the dawn of the renaissance of bacteriophage therapy, the full acceptation of bacteriophages as anti-bacterial agents requires the determination of their basic pharmacokinetic parameters. Such data, known for all conventional drugs used in human… read more here.
Keywords: medicine; biodistribution; vivo bacteriophage; bacteriophage ... See more keywords
A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers
Sign Up to like & getrecommendations! Published in 2022 at "Investigational New Drugs"
DOI: 10.1007/s10637-022-01237-3
Abstract: Ephrin type-A 2 (EphA2) is a transmembrane receptor expressed in epithelial cancers. We report on a phase I dose escalation and biodistribution study of DS-8895a, an anti-EphA2 antibody, in patients with advanced EphA2 positive cancers.… read more here.
Keywords: patients advanced; biodistribution; positive cancers; antibody ... See more keywords
Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.03.047
Abstract: Nanoparticle delivery systems are known to enhance the immune response to soluble antigens (Ags) and are thus a promising tool for the development of new vaccines. Our laboratory has engineered two different nanoparticulate systems in… read more here.
Keywords: biodistribution; nanocarriers coupling; cd8; vaccine nanocarriers ... See more keywords
Evaluation of domain of unknown function 1220 (DUF1220) for detection of human genome by quantitative polymerase chain reaction: Potential use in assessing the biodistribution of transplanted therapeutic human cells.
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2020.11.001
Abstract: The biodistribution profile of cell-based therapy products in animal models is important for evaluation of their safety and efficacy. Because of its quantitative nature and sensitivity, the quantitative polymerase chain reaction (qPCR) is a useful… read more here.
Keywords: biodistribution; duf1220; human genome; quantitative polymerase ... See more keywords
Chitosan stabilized camptothecin nanoemulsions: Development, evaluation and biodistribution in preclinical breast cancer animal mode.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.127
Abstract: Clinical use of camptothecin (CPT) is hindered due to its poor water and oil solubility, active lactone ring instability and non-targeted toxicity. Recently we reported formulation of camptothecin microemulsions with increased solubility for the improved… read more here.
Keywords: biodistribution; breast; cpt; camptothecin ... See more keywords
Fluorescence- and computed tomography for assessing the biodistribution of siRNA after intratracheal application in mice.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.02.025
Abstract: Pulmonary delivery of nucleic acids opens the possibility for direct treatment of lung diseases, like fibrosis, cancer, and infections. Lung retention and biodistribution of nucleic acids remain important issues for the development of suitable therapeutic… read more here.
Keywords: computed tomography; fluorescence; biodistribution; intratracheal application ... See more keywords
Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with 57Co‐porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.09.027
Abstract: Background and motivation: While small molecules can be used in cancer diagnosis there is a need for imageable diagnostic NanoParticles (NPs) that act as surrogates for the therapeutic NPs. Many NPs are composed of hydrophobic… read more here.
Keywords: biodistribution; chelation; cobalt; oep ... See more keywords