Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000463
Abstract: Characterization of the pharmacokinetics and biodistribution of therapeutic proteins (TPs) is a hot topic within the pharmaceutical industry, particularly with an ever-increasing catalog of novel modality TPs. Here, we review the current practices, and provide… read more here.
Keywords: biodistribution; characterizing pharmacokinetics; therapeutic proteins; biodistribution therapeutic ... See more keywords
Fc-Mediated Anomalous Biodistribution of Therapeutic Antibodies in Immunodeficient Mouse Models.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1958
Abstract: A critical benchmark in the development of antibody-based therapeutics is demonstration of efficacy in preclinical mouse models of human disease, many of which rely on immunodeficient mice. However, relatively little is known about how the… read more here.
Keywords: therapeutic antibodies; mouse models; biodistribution; anomalous biodistribution ... See more keywords