Enhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle Remodeling
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DOI: 10.1161/circresaha.122.321833
Abstract: Background: Cardiac contractile function requires high energy from mitochondria, and Ca2+ from the sarcoplasmic reticulum (SR). Via local Ca2+ transfer at close mitochondria-SR contacts, cardiac excitation feedforward regulates mitochondrial ATP production to match surges in… read more here.
Keywords: cardiac muscle; bioenergetics coupling; excitation bioenergetics; mitochondria tethering ... See more keywords